(Q39990999)

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The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors

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Europe PubMed Central

PubMed publication ID

16 September 2017

The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors (English)

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16 September 2017

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Kai-Uwe Eckardt

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Kai-Uwe Eckardt

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16 September 2017

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Christina Warnecke

1

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16 September 2017

Alexander Weidemann

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16 September 2017

Melanie Volke

3

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16 September 2017

Ruth Schietke

4

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16 September 2017

Xiaoqing Wu

5

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16 September 2017

Karl X Knaup

6

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16 September 2017

Thomas Hackenbeck

7

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16 September 2017

Wanja Bernhardt

8

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16 September 2017

Carsten Willam

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16 September 2017

Michael S Wiesener

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16 September 2017

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18 March 2008

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16 September 2017

Experimental Cell Research

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16 September 2017

314

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16 September 2017

10

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16 September 2017

2016-2027

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16 September 2017

The HIF pathway in cancer

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Targeting HIF-1 for cancer therapy

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Purification and characterization of hypoxia-inducible factor 1

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Oxygen sensing by HIF hydroxylases

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

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Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

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HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia

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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

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Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

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Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells

1 reference

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7 January 2021

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

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HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

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7 January 2021

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

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Acute postnatal ablation of Hif-2alpha results in anemia

1 reference

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

1 reference

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7 January 2021

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.

1 reference

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7 January 2021

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

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7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

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7 January 2021

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

1 reference

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7 January 2021

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

1 reference

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7 January 2021

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

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7 January 2021

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

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Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection.

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

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7 January 2021

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

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7 January 2021

The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1.

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MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity

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CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor

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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

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Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

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Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways

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The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP

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10.1016/J.YEXCR.2008.03.003

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

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