(Q34508481)

2 August 2017

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title

Chemical genomics in the global study of protein functions (English)

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2 August 2017

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X F Steven Zheng

1

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2 August 2017

Ting-Fung Chan

series ordinal

2

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2 August 2017

language of work or name

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1 February 2002

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

3

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2 August 2017

page(s)

197-205

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Chemical genetics resulting from a passion for synthetic organic chemistry.

2 August 2017

cites work

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7 January 2021

Chemical genetics: exploring and controlling cellular processes with chemical probes

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7 January 2021

Chemical genetics: ligand-based discovery of gene function

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7 January 2021

Chemical genetic approaches for the elucidation of signaling pathways

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7 January 2021

Sequence-specific DNA recognition by polyamides

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7 January 2021

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

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7 January 2021

Regulation of protein kinase C.

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7 January 2021

The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

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7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

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7 January 2021

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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7 January 2021

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

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7 January 2021

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells

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7 January 2021

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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7 January 2021

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

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7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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7 January 2021

Lactacystin, proteasome function, and cell fate

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7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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7 January 2021

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

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7 January 2021

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

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7 January 2021

Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases

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7 January 2021

The TOR signaling cascade regulates gene expression in response to nutrients

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7 January 2021

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

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7 January 2021

Signaling--2000 and beyond

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7 January 2021

Unnatural ligands for engineered proteins: new tools for chemical genetics

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7 January 2021

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

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7 January 2021

Design of allele-specific inhibitors to probe protein kinase signaling

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7 January 2021

Controlling signal transduction with synthetic ligands

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7 January 2021

A versatile synthetic dimerizer for the regulation of protein-protein interactions

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7 January 2021

Target-oriented and diversity-oriented organic synthesis in drug discovery

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7 January 2021

New roles for structure in biology and drug discovery

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7 January 2021

Analysis of yeast protein kinases using protein chips.

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7 January 2021

Genomics, gene expression and DNA arrays

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7 January 2021

Genomewide studies of histone deacetylase function in yeast

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7 January 2021

Functional discovery via a compendium of expression profiles

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7 January 2021

Drug target validation and identification of secondary drug target effects using DNA microarrays

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

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7 January 2021

Evolution and function of ubiquitin-like protein-conjugation systems

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7 January 2021

Histone methylation versus histone acetylation: new insights into epigenetic regulation

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7 January 2021

Acetylation of histones and transcription-related factors

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7 January 2021

The meteoric rise of regulated intracellular proteolysis

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7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

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7 January 2021

Two-dimensional gel electrophoresis: a powerful method to elucidate cellular responses to toxic compounds

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7 January 2021

Mass spectrometry and proteomics

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7 January 2021

Differential screening and mass mapping of proteins from premalignant and cancer cell lines using nonporous reversed-phase HPLC coupled with mass spectrometric analysis

1 reference

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7 January 2021

Isoelectric focusing nonporous RP HPLC: a two-dimensional liquid-phase separation method for mapping of cellular proteins with identification using MALDI-TOF mass spectrometry

1 reference

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7 January 2021

Prefractionation techniques in proteome analysis

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7 January 2021

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

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7 January 2021

Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome

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7 January 2021

Detection of multiple proteins in an antibody-based protein microarray system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

7 January 2021

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

7 January 2021

High-throughput isolation of Caenorhabditis elegans deletion mutants

1 reference

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7 January 2021

Genome-wide mutant collections: toolboxes for functional genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

7 January 2021

Genomic profiling of drug sensitivities via induced haploinsufficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

7 January 2021

Feedback control of mitosis in budding yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

7 January 2021

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

7 January 2021

Use of isogenic human cancer cells for high-throughput screening and drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2801%2902118-3

7 January 2021

10.1016/S1359-6446(01)02118-3

Identifiers

DOI

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2 August 2017

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