(Q34508545)

2 August 2017

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title

Genetic factors in the predisposition to drug-induced hypersensitivity reactions (English)

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2 August 2017

Munir Pirmohamed

1

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language of work or name

English

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publication date

3 February 2006

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2 August 2017

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2 August 2017

8

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2 August 2017

E20-6

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2 August 2017

1

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https://scigraph.springernature.com/pub.10.1208/aapsj080103

2 August 2017

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cites work

Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster

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Shaking the tree: mapping complex disease genes with linkage disequilibrium

7 July 2018

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Drug hypersensitivities: definition, epidemiology and risk factors

7 July 2018

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HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome

7 July 2018

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Medical genetics: a marker for Stevens-Johnson syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

An integrated haplotype map of the human major histocompatibility complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Severe drug rashes in three siblings simultaneously

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Immunopharmacology of hypersensitivity reactions to drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

The danger hypothesis--potential role in idiosyncratic drug reactions

7 July 2018

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The importance of being modest--reflections on the pharmacogenetics of abacavir

7 July 2018

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The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Genetic susceptibility to adverse drug reactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Initial sequencing and analysis of the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

The Sequence of the Human Genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Skin reactions to antibacterial agents in general practice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Serum anticonvulsant concentrations and the risk of drug induced skin eruptions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Metabolism of carbamazepine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Familial occurrence of hypersensitivity to phenytoin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Clinical and immunogenetic correlates of abacavir hypersensitivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Risk factor analysis of hypersensitivity reactions to abacavir

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Hypersensitivity related to abacavir in two members of a family

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Concordance of primary generalised epilepsy and carbamazepine hypersensitivity in monozygotic twins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2751420

Pathogenesis of hypersensitivity reactions to drugs in patients with HIV infection: allergic or toxic?

27 October 2018

1 reference

12 December 2020

Anticonvulsant hypersensitivity syndrome

1 reference

12 December 2020

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

1 reference

12 December 2020

Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s)

1 reference

12 December 2020

Protein-reactive metabolites of carbamazepine in mouse liver microsomes

1 reference

12 December 2020

Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs

1 reference

12 December 2020

Risk of Stevens-Johnson syndrome and toxic epider mal necrolysis during first weeks of antiepileptic therapy: a case-control study

1 reference

12 December 2020

Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS

1 reference

12 December 2020

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity

1 reference

12 December 2020

Predisposition to phenytoin hepatotoxicity assessed in vitro

1 reference

12 December 2020

Metabolism of carbamazepine and its epoxide metabolite in human and rat liver in vitro

1 reference

12 December 2020

Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions

1 reference

12 December 2020

Cutaneous hypersensitivity reactions due to thiacetazone in HIV-1 seropositive patients treated for tuberculosis

1 reference

12 December 2020

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro

1 reference

12 December 2020

Familial occurrence of fixed drug eruptions

1 reference

12 December 2020

Measurement of in vivo microsomal epoxide hydrolase activity in white subjects

1 reference

12 December 2020

Identifiers

DOI

10.1208/AAPSJ080103

1 reference

PubMed ID

16584129

Dimensions Publication ID

2 August 2017

0 references

1 reference

2 August 2017

1 reference

PubMed ID

16584129