(Q35035447)

5 August 2017

1 reference

title

The danger hypothesis--potential role in idiosyncratic drug reactions (English)

1 reference

5 August 2017

Munir Pirmohamed

1

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Dean J Naisbitt

object named as

Dean J Naisbitt

series ordinal

2

1 reference

ORCID Public Data File 2021

author name string

Fraser Gordon

series ordinal

3

1 reference

PubMed ID

12505285

5 August 2017

B Kevin Park

series ordinal

4

1 reference

PubMed ID

12505285

5 August 2017

language of work or name

English

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publication date

1 December 2002

1 reference

5 August 2017

1 reference

5 August 2017

181-182

1 reference

5 August 2017

55-63

1 reference

Danger: the view from the bottom of the cliff

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Sequential assessment of an antidrug antibody response in a patient with a systemic delayed-onset sulphonamide hypersensitivity syndrome reaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Induction of delayed-type hypersensitivity to sulfamethoxazole in mice: role of metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Danger signals: SOS to the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Natural adjuvants: endogenous activators of dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Sulfonamide-induced reactions in desensitized patients with AIDS--the role of covalent protein haptenation by sulfamethoxazole

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Mechanisms of halothane toxicity: novel insights

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Regulation of T cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Idiosyncratic drug reactions: the reactive metabolite syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Tolerance, danger, and the extended family

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Metabolic activation in drug allergies.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Role of T cells in drug allergies

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Adverse drug reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Adverse reactions to co-trimoxazole in HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Cutting Edge Commentary: A Copernican Revolution? Doubts About the Danger Theory

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

Factors Influencing the Incidence of Lamotrigine-Related Skin Rash

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900255-X

7 January 2021

10.1016/S0300-483X(02)00255-X

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12505285