(Q34509697)

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Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist.

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scholarly article

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20 February 2020

Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist (English)

1 reference

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20 February 2020

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20 February 2020

author name string

Nagako Banzawa

1

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20 February 2020

Shigeru Saito

2

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20 February 2020

Toshiaki Imagawa

3

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20 February 2020

Kenji Takahashi

5

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20 February 2020

Makoto Tominaga

6

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20 February 2020

Toshio Ohta

7

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20 February 2020

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publication date

30 September 2014

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20 February 2020

Journal of Biological Chemistry

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20 February 2020

289

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20 February 2020

46

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20 February 2020

31927-31939

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20 February 2020

Species differences and molecular determinant of TRPA1 cold sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Involvement of TRPA1 activation in acute pain induced by cadmium in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Analysis of transient receptor potential ankyrin 1 (TRPA1) in frogs and lizards illuminates both nociceptive heat and chemical sensitivities and coexpression with TRP vanilloid 1 (TRPV1) in ancestral vertebrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1 antagonists as potential analgesic drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1: the species difference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Polymodal ligand sensitivity of TRPA1 and its modes of interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1 and cold transduction: an unresolved issue?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Zinc activates damage-sensing TRPA1 ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1 acts as a cold sensor in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Molecular determinants of species-specific activation or blockade of TRPA1 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1 is a major oxidant sensor in murine airway sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Transient receptor potential A1 mediates an osmotically activated ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Targeting Ca2+ channels to treat pain: T-type versus N-type.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Molecular determinants of vanilloid sensitivity in TRPV1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231671

7 July 2018

H(2)S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Molecular basis for species-specific sensitivity to "hot" chili peppers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Heat and AITC activate green anole TRPA1 in a membrane-delimited manner.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586891

21 January 2018

Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25271161

12 December 2020

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Identifiers

10.1074/JBC.M114.586891

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25271161%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25271161%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25271161%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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