(Q34516867)

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Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

embryonal carcinoma

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

10

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Mary Ellen Moynahan

object named as

Mary Ellen Moynahan

8

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George J Bosl

6

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Darren R Feldman

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Darren R Feldman

4

0 references

Grazia Graziani

object named as

Grazia Graziani

2

0 references

author name string

Francesca Cavallo

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Cristina Antinozzi

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Jane Houldsworth

5

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Raju S K Chaganti

7

1 reference

Europe PubMed Central

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2 August 2017

Maria Jasin

9

1 reference

Europe PubMed Central

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2 August 2017

language of work or name

0 references

publication date

12 December 2012

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

e51563

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution 4.0 International

12 December 2012

1 reference

April 2022 Public Data File from Crossref

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describes a project that uses

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ImageQuant

2 references

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3520950/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway.

1 reference

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7 July 2018

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation.

1 reference

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7 July 2018

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

DNA damage response to the Mdm2 inhibitor nutlin-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Mechanism of replication-coupled DNA interstrand crosslink repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

1 reference

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7 July 2018

Medical treatment of advanced testicular cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Homologous recombination in DNA repair and DNA damage tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

The stem cell identity of testicular cancer

1 reference

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Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research.

1 reference

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First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure

1 reference

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A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors

1 reference

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7 July 2018

Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?

1 reference

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

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7 July 2018

Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

1 reference

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7 July 2018

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

1 reference

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Population pharmacokinetics of total and unbound plasma cisplatin in adult patients

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7 July 2018

Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors

1 reference

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7 July 2018

Curing metastatic cancer: lessons from testicular germ-cell tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Role of P53 and MDM2 in treatment response of human germ cell tumors

1 reference

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DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

Brca1 controls homology-directed DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

7 July 2018

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520950

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Characterization of molecular defects in xeroderma pigmentosum group F in relation to its clinically mild symptoms

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Sensitivity of testis tumour cells to chemotherapeutic drugs: role of detoxifying pathways

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Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT.

1 reference

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Inhibition of proliferation and induction of differentiation of pluripotent human embryonal carcinoma cells by osteogenic protein-1 (or bone morphogenetic protein-7).

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Isolation and characterization of a multipotent clone of human embryonal carcinoma cells.

1 reference

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Risk-adapted treatment choice in stage I nonseminomatous testicular germ cell cancer by regarding vascular invasion in the primary tumor: a prospective trial

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Measuring recombination proficiency in mouse embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Percentage of embryonal carcinoma and of vascular invasion predicts pathological stage in clinical stage I nonseminomatous testicular cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testicular germ-cell cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic risk factors that identify patients with clinical stage I nonseminomatous germ cell tumors at low risk and high risk for metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23251575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0051563

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2012PLoSO...751563C

0 references

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24 November 2022

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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