(Q34521033)

2 August 2017

title

X-ray structures and mechanism of the human serotonin transporter (English)

1 reference

2 August 2017

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Jonathan A Coleman

1

1 reference

2 August 2017

Evan M Green

series ordinal

2

1 reference

2 August 2017

Eric Gouaux

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

6 April 2016

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2 August 2017

number of pages

6

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inferred from page(s)

published in

Nature

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2 August 2017

volume

532

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2 August 2017

issue

7599

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2 August 2017

page(s)

334-339

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Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation

2 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Structural basis for action by diverse antidepressants on biogenic amine transporters

7 July 2018

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X-ray structure of dopamine transporter elucidates antidepressant mechanism

7 July 2018

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7 July 2018

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Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C

7 July 2018

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Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

7 July 2018

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Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter

7 July 2018

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7 July 2018

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Towards automated crystallographic structure refinement with phenix.refine

7 July 2018

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Crystal structure of a lipid G protein-coupled receptor

7 July 2018

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X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

7 July 2018

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SLC6 neurotransmitter transporters: structure, function, and regulation

7 July 2018

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Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

7 July 2018

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7 July 2018

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The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations

7 July 2018

1 reference

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Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

7 July 2018

1 reference

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Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes

7 July 2018

1 reference

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The expanded biology of serotonin

7 July 2018

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An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant

7 July 2018

1 reference

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Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters.

7 July 2018

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A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation.

7 July 2018

1 reference

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7 July 2018

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Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures

7 July 2018

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A competitive inhibitor traps LeuT in an open-to-out conformation

7 July 2018

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7 July 2018

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Serum vasoconstrictor, serotonin; isolation and characterization

7 July 2018

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

7 July 2018

1 reference

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Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

7 July 2018

1 reference

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Identification of a chloride ion binding site in Na+/Cl -dependent transporters.

7 July 2018

1 reference

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The functional impact of SLC6 transporter genetic variation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Membrane cholesterol modulates serotonin transporter activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Oligomerization of serotonin transporter and its functional consequences

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Comparative protein modelling by satisfaction of spatial restraints

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Ligand binding to the serotonin transporter: equilibria, kinetics, and ion dependence.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

The effect of N-linked glycosylation on activity of the Na(+)- and Cl(-)-dependent serotonin transporter expressed using recombinant baculovirus in insect cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

A simple method for displaying the hydropathic character of a protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

5-hydroxytryptamine uptake by rat brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Cloning of a serotonin transporter affected by antidepressants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

Cloning and expression of a functional serotonin transporter from rat brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898786

INHIBITION OF UPTAKE OF TRITIATED-NORADRENALINE IN THE INTACT RAT BRAIN BY IMIPRAMINE AND STRUCTURALLY RELATED COMPOUNDS.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE17629

High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE17629

Antibodies to major histocompatibility antigens produced by hybrid cell lines

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE17629

The effect of imipramine on central 5-hydroxytryptamine neurons

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27049939

12 December 2020

inferred from PubMed ID database lookup

Serotonin modulates the dissociation of [3H]imipramine from human platelet recognition sites

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27049939

12 December 2020

inferred from PubMed ID database lookup

External cysteine residues in the serotonin transporter

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27049939

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NATURE17629

1 reference

Dimensions Publication ID

2 August 2017

0 references

1 reference

2 August 2017

1 reference