(Q35011459)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter (English)

1 reference

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11 February 2020

1

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11 February 2020

Kasper B. Hansen

3

1 reference

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11 February 2020

Benny Bang-andersen

7

1 reference

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11 February 2020

Kristian Strømgaard

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Anders S Kristensen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

author name string

Lars Olsen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Olivier Taboureau

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Flemming S Jørgensen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Anne Marie Jørgensen

6

1 reference

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11 February 2020

Jan Egebjerg

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

language of work or name

English

0 references

publication date

5 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

11 February 2020

published in

1 reference

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11 February 2020

volume

285

1 reference

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11 February 2020

issue

3

1 reference

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11 February 2020

page(s)

2051-2063

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes

11 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Generation of a 3D model for human GABA transporter hGAT-1 using molecular modeling and investigation of the binding of GABA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

A competitive inhibitor traps LeuT in an open-to-out conformation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Mechanism for alternating access in neurotransmitter transporters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

The binding sites for cocaine and dopamine in the dopamine transporter overlap

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Bound to be different: neurotransmitter transporters meet their bacterial cousins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

What is an antidepressant binding site doing in a bacterial transporter?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Mechanism of chloride interaction with neurotransmitter:sodium symporters.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Identification of a chloride ion binding site in Na+/Cl -dependent transporters.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Serotonin transporters--structure and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Neurotransmitter transporters: molecular function of important drug targets

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Three-dimensional models of neurotransmitter transporters and their interactions with cocaine and S-citalopram

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Getting the message across: a recent transporter structure shows the way.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Putative drug binding conformations of monoamine transporters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

The chicken serotonin transporter discriminates between serotonin-selective reuptake inhibitors. A species-scanning mutagenesis study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Plasma membrane monoamine transporters: structure, regulation and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Permeation and gating residues in serotonin transporter

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Neurotransmitter transporters in the central nervous system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Single-channel currents produced by the serotonin transporter and analysis of a mutation affecting ion permeation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Comparative protein modelling by satisfaction of spatial restraints

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.072587

Mutational scanning of the human serotonin transporter reveals fast translocating serotonin transporter mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.072587

A putative three-dimensional arrangement of the human serotonin transporter transmembrane helices: a tool to aid experimental studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.072587

The cytoplasmic substrate permeation pathway of serotonin transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.072587

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.072587

Homology modeling of the serotonin transporter: insights into the primary escitalopram-binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.072587

Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804362

χ-Conotoxin and Tricyclic Antidepressant Interactions at the Norepinephrine Transporter Define a New Transporter Model

25 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.072587

A common binding site for tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors at the substrate recognition site of the neuronal sodium-dependent 5-hydroxytryptamine transporter

21 January 2018

1 reference

12 December 2020

Identification of a lithium interaction site in the gamma-aminobutyric acid (GABA) transporter GAT-1

1 reference

12 December 2020

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

1 reference

12 December 2020

Molecular dynamics simulations of Na+/Cl(-)-dependent neurotransmitter transporters in a membrane-aqueous system

1 reference

12 December 2020

Antidepressant binding to the porcine and human platelet serotonin transporters

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.072587

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19892699%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference