(Q34521923)

2 August 2017

title

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity (English)

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2 August 2017

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7

David S Miller

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2 August 2017

Dan Zhang

1

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2 August 2017

Xiaoming Hu

2

1 reference

2 August 2017

Li Qian

3

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2 August 2017

Shih-Heng Chen

4

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2 August 2017

Hui Zhou

5

1 reference

2 August 2017

Belinda Wilson

6

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2 August 2017

Jau-Shyong Hong

8

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2 August 2017

language of work or name

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13 January 2011

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Journal of Neuroinflammation

2 August 2017

published in

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2 August 2017

volume

8

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2 August 2017

issue

1

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2 August 2017

page(s)

3

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CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

2 August 2017

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7 July 2018

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Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity

7 July 2018

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7 July 2018

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Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement

7 July 2018

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The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase

7 July 2018

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

7 July 2018

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7 July 2018

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Phosphoinositide 3-kinase: diverse roles in immune cell activation

7 July 2018

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Phosphoinositide 3-kinase-dependent activation of Rac.

7 July 2018

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A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

7 July 2018

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Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system

7 July 2018

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Microglia as neuroprotective, immunocompetent cells of the CNS.

7 July 2018

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Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor

7 July 2018

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Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

7 July 2018

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Microglial interaction with beta-amyloid: implications for the pathogenesis of Alzheimer's disease

7 July 2018

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Phosphoinositide 3-kinase signalling pathways

7 July 2018

1 reference

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Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1

7 July 2018

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CR3: a general purpose adhesion-recognition receptor essential for innate immunity

7 July 2018

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Signaling by distinct classes of phosphoinositide 3-kinases

7 July 2018

1 reference

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'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils

7 July 2018

1 reference

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7 July 2018

NADPH oxidase: an update

1 reference

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Amyloid beta-peptide and its relationship with dementia in Lewy body disease.

7 July 2018

1 reference

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Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands

7 July 2018

1 reference

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CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

A MAC-1 attack: integrin functions directly challenged in knockout mice

7 July 2018

1 reference

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A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

7 July 2018

1 reference

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Integrin adhesion receptors: structure, function and implications for biomedicine

7 July 2018

1 reference

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Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

7 July 2018

1 reference

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CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

7 July 2018

1 reference

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Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Brain microglia constitutively express beta-2 integrins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in the Alzheimer's disease brain

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3027117

MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity

27 October 2018

1 reference

12 December 2020

The CD11/CD18 integrins: characterization of three novel LPS signaling receptors

1 reference

12 December 2020

Occurrence of diffuse amyloid deposits in the presubicular parvopyramidal layer in Alzheimer's disease

1 reference

12 December 2020

Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls

1 reference

12 December 2020

Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia

1 reference

12 December 2020

Identifiers

DOI

10.1186/1742-2094-8-3

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Dimensions Publication ID

2 August 2017

0 references

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2 August 2017

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