(Q35163957)

6 August 2017

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title

Phosphoinositide 3-kinase-dependent activation of Rac. (English)

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6 August 2017

1

Heidi C E Welch

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6 August 2017

W John Coadwell

2

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6 August 2017

Len R Stephens

series ordinal

3

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6 August 2017

Phillip T Hawkins

series ordinal

4

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6 August 2017

language of work or name

English

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publication date

1 July 2003

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6 August 2017

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6 August 2017

volume

546

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6 August 2017

issue

1

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6 August 2017

page(s)

93-97

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Rho GTPases and their effector proteins

6 August 2017

cites work

1 reference

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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

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Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation.

7 January 2021

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Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

7 January 2021

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PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

7 January 2021

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Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling

7 January 2021

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Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

7 January 2021

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The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes

7 January 2021

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p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes

7 January 2021

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Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils

7 January 2021

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The small GTP-binding protein Rac promotes the dissociation of gelsolin from actin filaments in neutrophils

7 January 2021

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

7 January 2021

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SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling

7 January 2021

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

7 January 2021

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Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

7 January 2021

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Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

7 January 2021

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alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

7 January 2021

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Signal-dependent membrane targeting by pleckstrin homology (PH) domains

7 January 2021

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

7 January 2021

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

7 January 2021

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7 January 2021

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

7 January 2021

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Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac

7 January 2021

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Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation

7 January 2021

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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

7 January 2021

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Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes

7 January 2021

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EPS8 and E3B1 transduce signals from Ras to Rac

7 January 2021

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An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

7 January 2021

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Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain

7 January 2021

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Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid

7 January 2021

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Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

7 January 2021

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Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

7 January 2021

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

7 January 2021

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Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

7 January 2021

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Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.

7 January 2021

1 reference

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Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

7 January 2021

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Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

7 January 2021

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Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3

7 January 2021

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

7 January 2021

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Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

7 January 2021

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Rho Family GTPases Bind to Phosphoinositide Kinases

7 January 2021

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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

7 January 2021

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Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

7 January 2021

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10.1016/S0014-5793(03)00454-X

7 January 2021

Identifiers

DOI

1 reference

6 August 2017

1 reference