(Q34524602)

2 August 2017

title

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch (English)

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2 August 2017

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6

Jennifer A Doudna

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2 August 2017

Dana C Nadler

2

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Christof Fellmann

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Christof Fellmann

4

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Avi Flamholz

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Avi Flamholz

3

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author name string

Benjamin L Oakes

1

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2 August 2017

Brett T Staahl

5

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2 August 2017

David F Savage

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2 August 2017

publication date

2 May 2016

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2 August 2017

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2 August 2017

volume

34

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2 August 2017

issue

6

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2 August 2017

page(s)

646-651

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STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

2 August 2017

cites work

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7 July 2018

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Photoactivatable CRISPR-Cas9 for optogenetic genome editing

7 July 2018

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Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display

7 July 2018

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7 July 2018

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Inducible in vivo genome editing with CRISPR-Cas9

7 July 2018

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A split-Cas9 architecture for inducible genome editing and transcription modulation

7 July 2018

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Synthetic protein switches: design principles and applications

7 July 2018

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Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

7 July 2018

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Genome editing. The new frontier of genome engineering with CRISPR-Cas9

7 July 2018

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Protein engineering of Cas9 for enhanced function

7 July 2018

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7 July 2018

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Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

7 July 2018

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An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells

7 July 2018

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Development and applications of CRISPR-Cas9 for genome engineering

7 July 2018

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Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

7 July 2018

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Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

7 July 2018

1 reference

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

7 July 2018

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Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

7 July 2018

1 reference

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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

7 July 2018

1 reference

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DNA targeting specificity of RNA-guided Cas9 nucleases

7 July 2018

1 reference

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CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast

7 July 2018

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Hot spots for allosteric regulation on protein surfaces

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Rapid diversification of cell signaling phenotypes by modular domain recombination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Synthetic protein scaffolds provide modular control over metabolic flux.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Linking the functions of unrelated proteins using a novel directed evolution domain insertion method

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Evolution of the protein repertoire

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Initial sequencing and analysis of the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Ligand-activated site-specific recombination in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Transcriptional activation by tetracyclines in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Guide RNA functional modules direct Cas9 activity and orthogonality

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

A yeast sensor of ligand binding.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4900928

Differential expression analysis for sequence count data

27 October 2018

1 reference

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Production and purification of lentiviral vectors

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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

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7 January 2021

An optimized microRNA backbone for effective single-copy RNAi

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Enzymatic assembly of DNA molecules up to several hundred kilobases

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A third-generation lentivirus vector with a conditional packaging system

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Identifiers

DOI

10.1038/NBT.3528

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2 August 2017

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2 August 2017

1 reference