(Q34534194)

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Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

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scholarly article

1 reference

Europe PubMed Central

2 August 2017

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress (English)

1 reference

Europe PubMed Central

2 August 2017

0 references

Werner syndrome

1 reference

based on heuristic

inferred from title

author name string

Monika Aggarwal

1

1 reference

Europe PubMed Central

2 August 2017

Joshua A Sommers

2

1 reference

Europe PubMed Central

2 August 2017

Robert H Shoemaker

3

1 reference

Europe PubMed Central

2 August 2017

Robert M Brosh

4

1 reference

Europe PubMed Central

2 August 2017

language of work or name

0 references

publication date

10 January 2011

1 reference

Europe PubMed Central

2 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

2 August 2017

108

1 reference

Europe PubMed Central

2 August 2017

4

1 reference

Europe PubMed Central

2 August 2017

1525-1530

1 reference

Europe PubMed Central

2 August 2017

The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

RecQ helicases: multifunctional genome caretakers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

DNA replication fork proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

1 reference

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7 July 2018

Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality

1 reference

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7 July 2018

Helicases as prospective targets for anti-cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Amplifying tumour-specific replication lesions by DNA repair inhibitors - a new era in targeted cancer therapy

1 reference

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7 July 2018

DNA repair pathways as targets for cancer therapy

1 reference

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7 July 2018

Human premature aging, DNA repair and RecQ helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

RecQ helicases: caretakers of the genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

Genetic syndromes in man with potential relevance to the pathobiology of aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029756

7 July 2018

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006423108

21 January 2018

G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006423108

21 January 2018

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

https://pubmed.ncbi.nlm.nih.gov/21220316

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21220316

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21220316

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1006423108

1 reference

Europe PubMed Central

2 August 2017

2011PNAS..108.1525A

0 references

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

ResearchGate publication ID

0 references

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