(Q34540545)

2 August 2017

1 reference

title

A Pluridimensional View of Biased Agonism (English)

1 reference

2 August 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Michel Bouvier

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Lucas T Parreiras-E-Silva

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

publication date

16 September 2016

1 reference

2 August 2017

published in

Molecular Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

90

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

587-595

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

31 May 2020

cites work

1 reference

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

21 January 2018

1 reference

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Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling

21 January 2018

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Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

21 January 2018

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https://api.crossref.org/works/10.1124%2FMOL.116.105940

Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design

21 January 2018

1 reference

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Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes

21 January 2018

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Imaging of persistent cAMP signaling by internalized G protein-coupled receptors

21 January 2018

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Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET.

21 January 2018

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Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

21 January 2018

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Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.

21 January 2018

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Energy landscapes as a tool to integrate GPCR structure, dynamics, and function

21 January 2018

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Cellular and subcellular context determine outputs from signaling biosensors

21 January 2018

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Model systems for the study of seven-transmembrane-segment receptors

21 January 2018

1 reference

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β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation.

21 January 2018

1 reference

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Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits

21 January 2018

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Retromer terminates the generation of cAMP by internalized PTH receptors

21 January 2018

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Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.

21 January 2018

1 reference

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Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization

21 January 2018

1 reference

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Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

21 January 2018

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Protean agonism at histamine H3 receptors in vitro and in vivo

21 January 2018

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Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties

21 January 2018

1 reference

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Equilibrium and kinetic selectivity profiling on the human adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Drug-target residence time--a case for G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Dynamic personalities of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Conformational biosensors reveal GPCR signalling from endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P acts as a biased agonist toward neuropeptide and chemokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Pertussis toxin separates two muscarinic receptor-effector mechanisms in the striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Agonist-receptor efficacy. II. Agonist trafficking of receptor signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

What is pharmacological 'affinity'? Relevance to biased agonism and antagonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

A simple method for quantifying functional selectivity and agonist bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

The role of kinetic context in apparent biased agonism at GPCRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Role of phosphorylation in desensitization of the beta-adrenoceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

The dynamic process of β(2)-adrenergic receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Multiple mechanisms of serotonergic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Technology combination to address GPCR allosteric modulator drug-discovery pitfalls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Differential signal transduction by five splice variants of the PACAP receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Investigation of the fate of type I angiotensin receptor after biased activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Non-canonical signaling of the PTH receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Endosomal generation of cAMP in GPCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Regulation of receptor tyrosine kinase signaling by endocytic trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

The importance of ligands for G protein-coupled receptor stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.105940

21 January 2018

Identifiers

DOI

10.1124/MOL.116.105940

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27638872%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference