(Q34545851)

2 August 2017

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title

The role of megalin (LRP-2/Gp330) during development (English)

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2 August 2017

Carolyn E Fisher

1

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2 August 2017

Sarah E M Howie

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

8 June 2006

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2 August 2017

published in

Developmental Biology

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2 August 2017

volume

296

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2 August 2017

issue

2

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2 August 2017

page(s)

279-297

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Cubilin and megalin: partners in lipoprotein and vitamin metabolism

2 August 2017

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Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule

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Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

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Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).

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Megalin binds and mediates cellular internalization of folate binding protein

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The CUB domain. A widespread module in developmentally regulated proteins

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Effects of azasteroids on growth and development of the free-living stages of Nippostrongylus brasiliensis and Nematospiroides dubius

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Receptor-mediated endocytosis: insights from the lipoprotein receptor system

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Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator

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39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

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A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney

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Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison

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Possible antiestrogenic activity of lindane in female rats.

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Fertilizing Capacity of Spermatozoa deposited into the Fallopian Tubes

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

7 January 2021

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Megalin and cubilin, role in proximal tubule function and during development

7 January 2021

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Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein

7 January 2021

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Membrane receptors for endocytosis in the renal proximal tubule.

7 January 2021

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Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

7 January 2021

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Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus

7 January 2021

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Ultrastructural analysis of pathologic lesions in sterol-deficient Nippostrongylus brasiliensis larvae

7 January 2021

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The hedgehog signaling network

7 January 2021

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Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex

7 January 2021

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Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes

7 January 2021

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Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema.

7 January 2021

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Collecting duct morphogenesis.

7 January 2021

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Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

7 January 2021

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Retinol administration to superovulated ewes improves in vitro embryonic viability

7 January 2021

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Exocytosis and endocytosis in the thyroid follicle cell

7 January 2021

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Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids

7 January 2021

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Decreased expression of calcium-sensing receptor messenger ribonucleic acids in parathyroid adenomas

7 January 2021

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Ascaris suum: continuous perfusion of the pseudocoelom and nutrient absorption.

7 January 2021

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The cytoskeleton, endocytosis and cell polarity in the mouse preimplantation embryo.

7 January 2021

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Molecular mechanisms of primary hypercalciuria

7 January 2021

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Temporal requirement for hedgehog signaling in ventral telencephalic patterning.

7 January 2021

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The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless

7 January 2021

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The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin

7 January 2021

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Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

7 January 2021

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Pax 6: mastering eye morphogenesis and eye evolution

7 January 2021

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Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly

7 January 2021

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Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

7 January 2021

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The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

7 January 2021

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Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins

7 January 2021

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Role of endocytosis in cellular uptake of sex steroids.

7 January 2021

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Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo

7 January 2021

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7 January 2021

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Expression and regulation of LRP-2/megalin in epithelial cells lining the efferent ducts and epididymis during postnatal development

7 January 2021

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Lipoprotein receptors in the nervous system

7 January 2021

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1alpha-Hydroxylase and the action of vitamin D.

7 January 2021

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Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

7 January 2021

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Megalin antagonizes activation of the parathyroid hormone receptor.

7 January 2021

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Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.

7 January 2021

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Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types of hyperoxic lung

7 January 2021

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The mammalian low-density lipoprotein receptor family

7 January 2021

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Sonic hedgehog induces the segregation of patched and smoothened in endosomes

7 January 2021

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Role of the Drosophila patched gene in positional signalling

7 January 2021

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Monoclonal anti-parathyroid antibodies interfering with a Ca2+-sensor of human parathyroid cells

7 January 2021

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HYPERPARATHYROIDISM IS ASSOCIATED WITH REDUCED EXPRESSION OF A PARATHYROID CALCIUM RECEPTOR MECHANISM DEFINED BY MONOCLONAL ANTIPARATHYROID ANTIBODIES

7 January 2021

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The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain

7 January 2021

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The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border

7 January 2021

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Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats

7 January 2021

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Identification of a CpG island in the human LRP-2 gene and analysis of its methylation status in parathyroid adenomas

7 January 2021

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Vitamin E as an antioxidant of the lung: mechanisms of vitamin E delivery to alveolar type II cells

7 January 2021

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Molecular Dissection of the Intrinsic Factor-Vitamin B12Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding

7 January 2021

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Kidney morphogenesis: cellular and molecular regulation

7 January 2021

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Ultrastructure and permeability of intercellular contacts of developing proximal tubule in the rat kidney

7 January 2021

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Differentiation of the vacuolar apparatus in cells of the developing proximal tubule in the rat kidney

7 January 2021

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Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins

7 January 2021

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Activity and form of sulfated glycoprotein 2 (clusterin) from cultured Sertoli cells, testis, and epididymis of the rat.

7 January 2021

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Megalin knockout mice as an animal model of low molecular weight proteinuria.

7 January 2021

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Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

7 January 2021

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Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants

7 January 2021

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Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release

7 January 2021

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Thyroid dysfunction in megalin deficient mice

7 January 2021

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A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily

7 January 2021

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Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein

7 January 2021

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7 January 2021

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Identification of a heparin-binding region of rat thyroglobulin involved in megalin binding

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Megalin (gp330) is an endocytic receptor for thyroglobulin on cultured fisher rat thyroid cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release

7 January 2021

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Megalin in thyroid physiology and pathology

7 January 2021

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Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Megalin and the neurodevelopmental biology of sonic hedgehog and retinol

7 January 2021

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Megalin functions as an endocytic sonic hedgehog receptor

7 January 2021

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Ultrastructural localization of megalin in the rat cochlear duct

7 January 2021

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Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia

7 January 2021

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The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins

7 January 2021

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Low density lipoprotein receptor-related protein-2 expression in efferent duct and epididymal epithelia: evidence in rats for its in vivo role in endocytosis of apolipoprotein J/clusterin

7 January 2021

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The Adaptor Protein ARH Escorts Megalin to and through Endosomes

7 January 2021

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Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

7 January 2021

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Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles

7 January 2021

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gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex

7 January 2021

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Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex

7 January 2021

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Functional domains of the receptor-associated protein (RAP)

7 January 2021

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Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions

7 January 2021

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Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule

7 January 2021

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Defects in enteric innervation and kidney development in mice lacking GDNF

7 January 2021

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Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Identification of low density lipoprotein receptor-related protein-2/megalin as an endocytic receptor for seminal vesicle secretory protein II.

7 January 2021

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Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

The membrane composition of coated pits, microvilli, endosomes, and lysosomes is distinctive in the rat kidney proximal tubule cell

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Interpretation of isolated agenesis of the pituitary

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

LRP2/megalin is required for patterning of the ventral telencephalon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Plasminogen activator in early embryogenesis: enzyme production by trophoblast and parietal endoderm

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Identification of an apical sorting determinant in the cytoplasmic tail of megalin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Co-expression and interaction of cubilin and megalin in the adult male rat reproductive system

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Cavitation in the mouse preimplantation embryo: and the origin of nascent blastocoele fluid

7 January 2021

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Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Defective forebrain development in mice lacking gp330/megalin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2.

7 January 2021

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A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Quartz inactivates alpha 1-antiproteinase: possible role in mineral dust-induced emphysema

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2006.06.007

10.1016/J.YDBIO.2006.06.007

7 January 2021

Identifiers

DOI

1 reference

2 August 2017

1 reference