(Q34565011)

English

Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

H Modi

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

L Li

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

S Chu

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

J Rossi

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

J-K Yee

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

R Bhatia

6

1 reference

Europe PubMed Central

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3 August 2017

publication date

12 November 2010

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

305-312

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells

1 reference

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

1 reference

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

1 reference

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A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase

1 reference

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Specific targeted therapy of chronic myelogenous leukemia with imatinib

1 reference

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High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia

1 reference

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Critical role for Gab2 in transformation by BCR/ABL

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Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes

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The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl

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Lentiviral vectors for enhanced gene expression in human hematopoietic cells

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Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity

1 reference

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Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

1 reference

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7 July 2018

Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia

1 reference

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7 July 2018

Bcr phosphorylated on tyrosine 177 binds Grb2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3036781

7 July 2018

Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells

1 reference

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7 July 2018

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1 reference

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7 July 2018

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

2 references

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7 July 2018

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Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.

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Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

1 reference

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Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study

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21 January 2018

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

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Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli

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Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years.

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21 January 2018

Effect of mutational inactivation of tyrosine kinase activity on BCR/ABL-induced abnormalities in cell growth and adhesion in human hematopoietic progenitors

1 reference

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21 January 2018

BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia

1 reference

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Grb2 signaling in cell motility and cancer

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Identifiers

10.1038/LEU.2010.257

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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