(Q35104353)

6 August 2017

1 reference

title

High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia (English)

1 reference

6 August 2017

1 reference

Stephan M Feller

1

1 reference

PubMed ID

12688310

6 August 2017

Gabriele Tuchscherer

series ordinal

2

1 reference

PubMed ID

12688310

6 August 2017

Jan Voss

series ordinal

3

1 reference

6 August 2017

1 March 2003

1 reference

6 August 2017

1 reference

6 August 2017

44

1 reference

6 August 2017

411-427

1 reference

6 August 2017

3

1 reference

The biology of chronic myeloid leukemia

6 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

21 January 2018

Chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Molecular pathogenesis of chronic myeloid leukemia: implications for new therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Telomere dynamics and genetic instability in disease progression of chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Subgroup of patients with Philadelphia-positive chronic myelogenous leukemia characterized by a deletion of 9q proximal to ABL gene: expression profiling, resistance to interferon therapy, and poor prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Recent advancements in the treatment of chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Pathogenesis and treatment of Ph+ leukemia: recent insights from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Modeling Philadelphia chromosome positive leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Modelling haematopoietic malignancies in the mouse and therapeutical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Physiological signals and oncogenesis mediated through Crk family adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Transforming genes in chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Molecular defects associated with the acute phase CML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Understanding Ras: 'it ain't over 'til it's over'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Crk family adaptors-signalling complex formation and biological roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

PI3-kinase inhibition: a target for drug development?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

BCR/ABL regulation of PI-3 kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Phosphatidyl inositol signaling by BCR/ABL: opportunities for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

PTEN and myotubularin: novel phosphoinositide phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The role of STATs in transcriptional control and their impact on cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

STAT signaling in the pathogenesis and treatment of leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Chronic myeloid leukemia: current treatment options

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Imatinib mesylate--a new oral targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cancer immunotherapy: the interferon-alpha experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Perspectives on the development of a molecularly targeted agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Research on resistance to cancer drug Gleevec

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cerebral oedema as a possible complication of treatment with imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

ARG tyrosine kinase activity is inhibited by STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Effects of combinations of therapeutic agents on the proliferation of progenitor cells in chronic myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: a translational perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

STI571: a paradigm of new agents for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Multifaceted approach to the treatment of bcr-abl-positive leukemias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Regulation of cell death by the Abl tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Innovative therapy for chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Gene therapy for chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Antisense therapeutics in chronic myeloid leukaemia: the promise, the progress and the problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Peptide aptamers: powerful new tools for molecular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

RNAi: nature abhors a double-strand

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Adoptive immunotherapy following allogeneic bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

CML vaccines as a paradigm of the specific immunotherapy of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Modular peptide recognition domains in eukaryotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

No longer an exclusive club: eukaryotic signalling domains in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Implications of SH3 domain structure and dynamics for protein regulation and drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

New intracellular targets for therapeutic drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

SH2 and SH3 domains: potential targets for anti-cancer drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

SH2 and SH3 domains as targets for anti-proliferative agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Progress in the development of inhibitors of SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

SH2 domain inhibition: a problem solved?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The role of Gads in hematopoietic cell signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Left-handed polyproline II helices commonly occur in globular proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The isoform-specific stretch of hSos1 defines a new Grb2-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Differential interactions of human Sos1 and Sos2 with Grb2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Grb2 SH3 binding to peptides from Sos: evaluation of a general model for SH3-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The structure and function of proline-rich regions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Can we infer peptide recognition specificity mediated by SH3 domains?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Novel recognition mode between Vav and Grb2 SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Critical role for Gab2 in transformation by BCR/ABL

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

GRB2: a pivotal protein in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Structure-based design of compounds inhibiting Grb2-SH2 mediated protein-protein interactions in signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Specificity and affinity motifs for Grb2 SH2-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Selective GRB2 SH2 inhibitors as anti-Ras therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Effect of potent and selective inhibitors of the Grb2 SH2 domain on cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

A novel, specific interaction involving the Csk SH3 domain and its natural ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

A specific intermolecular association between the regulatory domains of a Tec family kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Rational development of cell-penetrating high affinity SH3 domain binding peptides that selectively disrupt the signal transduction of Crk family adapters. Amgen Peptide Technology Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Identification of D-peptide ligands through mirror-image phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

D-amino acids in animal peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Trojan peptides: the penetratin system for intracellular delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Improving SH3 domain ligand selectivity using a non-natural scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Targeting Molecular Recognition: Exploring the Dual Role of Functional Pseudoprolines in the Design of SH3 Ligands This work was supported by the Swiss National Science Foundation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cell-penetrating peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Receptor tyrosine kinases as targets for anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Tyrosine kinase signalling in breast cancer: modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Inhibitors of Ras signal transduction as antitumor agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Organ targeting in vivo using phage display peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Biopanning and rapid analysis of selective interactive ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Targeting the prostate for destruction through a vascular address

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Molecular specialization of breast vasculature: a breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

EPS8 and E3B1 transduce signals from Ras to Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Oncogene inactivation in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation withGRB2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000037930

10.1080/1042819021000037930

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12688310