(Q34011982)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

review article

1 reference

title

PI3-kinase inhibition: a target for drug development? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

author name string

M D Waterfield

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

publication date

1 September 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

Trends in Molecular Medicine

9 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

page(s)

347-357

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

9 November 2019

cites work

1 reference

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7 January 2021

Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Structure and function of phosphoinositide 3-kinases.

1 reference

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7 January 2021

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

1 reference

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7 January 2021

Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

1 reference

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7 January 2021

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

ATM: a mediator of multiple responses to genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Perspectives: cell biology. All creatures great and small

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

PIK3CA as an oncogene in cervical cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Phospholipid-binding protein domains

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

PI 3-kinase: a pivotal pathway in T-cell activation?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Moving in mysterious ways

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2800%2901770-6

7 January 2021

10.1016/S1357-4310(00)01770-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference