(Q34581717)

3 August 2017

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title

The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects (English)

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3 August 2017

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1

Ann M Bode

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3 August 2017

Zigang Dong

2

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3 August 2017

publication date

1 April 2002

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Critical Reviews in Oncology Hematology

3 August 2017

published in

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3 August 2017

volume

42

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3 August 2017

issue

1

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3 August 2017

page(s)

5-24

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Arsenic: health effects, mechanisms of actions, and research issues

3 August 2017

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Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic

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7 January 2021

Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase

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7 January 2021

DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine

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7 January 2021

Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity

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Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes

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7 January 2021

Arsenic species that cause release of iron from ferritin and generation of activated oxygen

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The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice

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72-kDa stress protein (hsp72) induced by administration of dimethylarsinic acid to mice accumulates in alveolar flat cells of lung, a target organ for arsenic carcinogenesis

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Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice.

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7 January 2021

Metals and disorders of cell accumulation: modulation of apoptosis and cell proliferation

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7 January 2021

Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices

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7 January 2021

Arsenic inhibits NF-kappaB-mediated gene transcription by blocking IkappaB kinase activity and IkappaBalpha phosphorylation and degradation

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7 January 2021

Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation

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7 January 2021

No point mutation of Ha-ras or p53 genes expressed in preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants

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7 January 2021

Responses of preneoplastic epidermal cells to tumor promoters and growth factors: use of promoter-resistant variants for mechanism studies.

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7 January 2021

Tumour promoter induces anchorage independence irreversibly

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7 January 2021

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

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7 January 2021

MAPKs: new JNK expands the group

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

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7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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7 January 2021

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

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7 January 2021

Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancers

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7 January 2021

The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway

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7 January 2021

Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite

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7 January 2021

Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase

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7 January 2021

Different mechanisms of c-Jun NH(2)-terminal kinase-1 (JNK1) activation by ultraviolet-B radiation and by oxidative stressors

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7 January 2021

Signal transduction pathways regulated by arsenate and arsenite

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7 January 2021

Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors

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7 January 2021

Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.

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7 January 2021

Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos

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7 January 2021

Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling

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7 January 2021

Sodium arsenite inhibits terminal differentiation of murine C3H 10T1/2 preadipocytes

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7 January 2021

Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure

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7 January 2021

fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.

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7 January 2021

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

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7 January 2021

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

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7 January 2021

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

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7 January 2021

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

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7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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7 January 2021

AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells.

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Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells

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7 January 2021

c-fos induction by heat, arsenite, and cadmium is mediated by a heat shock element in its promoter

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7 January 2021

Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases.

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7 January 2021

Protein kinase C. Seeing two domains

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7 January 2021

Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases

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7 January 2021

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7 January 2021

The NF-kappa B and I kappa B proteins: new discoveries and insights

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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Regulation of NF-kappa B activation by MAP kinase cascades.

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7 January 2021

Clinically relevant findings

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7 January 2021

NF-kappa B: ten years after

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7 January 2021

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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7 January 2021

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

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7 January 2021

Roles of nuclear factor kappaB in neuronal survival and plasticity

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7 January 2021

Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways

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7 January 2021

Arsenic induces oxidant stress and NF-KB activation in cultured aortic endothelial cells

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7 January 2021

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

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7 January 2021

Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways

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7 January 2021

Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation

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7 January 2021

Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiologic study

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7 January 2021

Arsenic trioxide and the growth of human T-cell leukemia virus type I infected T-cell lines

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7 January 2021

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

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7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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7 January 2021

Induction of p53 protein expression by sodium arsenite

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7 January 2021

Effects of exposure protocols on induction of kinetochore-plus and -minus micronuclei by arsenite in diploid human fibroblasts

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7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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7 January 2021

The role of ATM in DNA damage responses and cancer

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7 January 2021

Arsenic disrupts cellular levels of p53 and mdm2: a potential mechanism of carcinogenesis

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7 January 2021

Expression of p53 in arsenic-related and sporadic basal cell carcinoma

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7 January 2021

Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan

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7 January 2021

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

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7 January 2021

Sodium arsenite-induced chromosomal aberrations in the Xq arm of Chinese hamster cell lines

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7 January 2021

Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines

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7 January 2021

Molecular aspects of arsenic stress

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7 January 2021

The role of oxidative DNA damage in human arsenic carcinogenesis: detection of 8-hydroxy-2'-deoxyguanosine in arsenic-related Bowen's disease.

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7 January 2021

Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite

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7 January 2021

NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells

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7 January 2021

Arsenite induces DNA-protein crosslinks and cytokeratin expression in the WRL-68 human hepatic cell line

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7 January 2021

DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells

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7 January 2021

Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis

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7 January 2021

Reactions of arsenic(III) and arsenic(V) species with glutathione

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7 January 2021

Arsenic and antimony: comparative approach on mechanistic toxicology

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7 January 2021

Metal carcinogenesis: mechanistic implications

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7 January 2021

Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein

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7 January 2021

Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro

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7 January 2021

Expression of bcl-2, p53 and Ki-67 in arsenical skin cancers

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7 January 2021

Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore

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7 January 2021

Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

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7 January 2021

Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis

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7 January 2021

Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis

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7 January 2021

Arsenic trioxide, a novel mitochondriotoxic anticancer agent?

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7 January 2021

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations

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7 January 2021

Dithiothreitol enhances arsenic trioxide-induced apoptosis in NB4 cells

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7 January 2021

Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals

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7 January 2021

Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice

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7 January 2021

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

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7 January 2021

Acute promyelocytic leukemia: Cellular and molecular basis of differentiation and apoptosis

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7 January 2021

Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia

1 reference

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7 January 2021

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Arsenic: a new place?

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Retinoic acid syndrome induced by arsenic trioxide in treating recurrent all-trans retinoic acid resistant acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Arsenic trioxide inhibits neuroblastoma growth in vivo and promotes apoptotic cell death in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Pathologic, cytogenetic and molecular assessment of acute promyelocytic leukemia patients treated with arsenic trioxide (As2O3).

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

The biology of chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Effect of arsenic trioxide on cell cycle arrest in head and neck cancer cell line PCI-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Arsenic-induced apoptosis in malignant cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Induction of mitosis-mediated apoptosis by sodium arsenite in HeLa S3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

Sodium arsenite reduces proliferation of human activated T-cells by inhibition of the secretion of interleukin-2

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2801%2900215-3

7 January 2021

10.1016/S1040-8428(01)00215-3

Identifiers

DOI

1 reference

release_zm6c3cfv4vfrjcpda5mtznlsfa

3 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zm6c3cfv4vfrjcpda5mtznlsfa

24 November 2022

mapped directly with Wikidata item

1 reference