(Q34583158)

3 August 2017

title

HdmX overexpression inhibits oncogene induced cellular senescence (English)

1 reference

3 August 2017

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

20 June 2024

author name string

Kevin Kelley

2

1 reference

3 August 2017

Rebecca Tuttle

3

1 reference

3 August 2017

Kelly R. Miller

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

20 June 2024

Steven J. Berberich

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

20 June 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20724842

20 June 2024

publication date

23 August 2010

1 reference

full work available at URL

3 August 2017

number of pages

7

1 reference

based on heuristic

inferred from page(s)

https://europepmc.org/articles/pmc3041169?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20724842/pdf/?tool=EBI

20 June 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20724842/?tool=EBI

20 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

https://europepmc.org/articles/PMC3041169

20 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

https://europepmc.org/articles/PMC3041169?pdf=render

20 June 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

https://doi.org/10.4161/cc.9.16.12779

20 June 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724842

http://www.tandfonline.com/doi/pdf/10.4161/cc.9.16.12779

20 June 2024

1 reference

Crossref

DOI

10.4161/CC.9.16.12779

https://api.crossref.org/works/10.4161/CC.9.16.12779

20 June 2024

1 reference

3 August 2017

volume

9

1 reference

3 August 2017

issue

16

1 reference

3 August 2017

page(s)

3376-3382

1 reference

Paradoxical suppression of cellular senescence by p53

3 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Identification and characterization of the first small molecule inhibitor of MDMX

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Full-length hdmX transcripts decrease following genotoxic stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Restoration of p53 function leads to tumour regression in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

MDMX regulation of p53 response to ribosomal stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Tumor cell senescence in cancer treatment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Oncogenic ras and p53 cooperate to induce cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3041169

Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FCC.9.16.12779

Hdmx stabilizes Mdm2 and p53

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20724842

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/CC.9.16.12779

1 reference

3 August 2017

1 reference

3 August 2017

1 reference