(Q34585071)

3 August 2017

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title

Strategies for increasing drug delivery to the brain: focus on brain lymphoma (English)

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3 August 2017

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Tali Siegal

1

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3 August 2017

Ester Zylber-Katz

series ordinal

2

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3 August 2017

language of work or name

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1 January 2002

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Clinical Pharmacokinetics

3 August 2017

published in

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3 August 2017

volume

41

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3 August 2017

issue

3

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3 August 2017

page(s)

171-186

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The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery

3 August 2017

cites work

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First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate

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Cognitive outcomes and long-term follow-up results after enhanced chemotherapy delivery for primary central nervous system lymphoma.

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Unusual cervical spinal cord toxicity associated with intra-arterial carboplatin, intra-arterial or intravenous etoposide phosphate, and intravenous cyclophosphamide in conjunction with osmotic blood brain-barrier disruption in the vertebral artery.

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12 December 2020

In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors

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12 December 2020

Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers

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12 December 2020

Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas

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Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means

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Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000?

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Prognostic significance of 111indium-DTPA CSF flow studies in leptomeningeal metastases

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12 December 2020

Cerebrospinal fluid drug levels of leukemic children receiving intravenous 5 g/m2 methotrexate

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12 December 2020

Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration

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12 December 2020

Variability in methotrexate serum and cerebrospinal fluid pharmacokinetics in children with acute lymphocytic leukemia: relation to assay methodology and physiological variables

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12 December 2020

Pharmacokinetic Modeling of Plasma and Cerebrospinal Fluid Methotrexate after High-Dose Intravenous Infusion in Children

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12 December 2020

Intrathecal chemotherapy for treatment of overt meningeal leukemia: comparison between intraventricular and traditional intralumbar route

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12 December 2020

Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics

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12 December 2020

Pharmacokinetics of methotrexate in the extracellular fluid of brain C6-glioma after intravenous infusion in rats

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12 December 2020

Increasing volume of distribution to the brain with interstitial infusion: dose, rather than convection, might be the most important factor.

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12 December 2020

Effect of dose and repeat intravenous 24 hr infusions of methotrexate on cerebrospinal fluid availability in children with hematological malignancies

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12 December 2020

Microvessel organization and structure in experimental brain tumors: microvessel populations with distinctive structural and functional properties

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12 December 2020

A novel chemical delivery system for brain targeting

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12 December 2020

Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections

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12 December 2020

The blood-brain barrier as a target for pharmacological modulation

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12 December 2020

Influence of barrier-crossing limitations on the amount of macromolecular drug taken up by its target

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12 December 2020

Chemotherapy of brain tumors

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12 December 2020

Pharmacokinetics of methotrexate in the cerebrospinal fluid after intracerebroventricular administration in patients with meningeal carcinomatosis and altered cerebrospinal fluid flow dynamics

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Therapeutic management of primary central nervous system lymphoma: lessons from prospective trials

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Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood-brain tumor barrier in the treatment of intracranial neoplasms.

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Influence of schedule of administration on methotrexate penetration in brain tumours.

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ACNU, MTX and 5-FU penetration of rat brain tissue and tumors

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Trends in primary cerebral lymphoma

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12 December 2020

Quantification and pharmacokinetics of blood-brain barrier disruption in humans

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12 December 2020

Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

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Incidence, clinicopathological features and outcome of primary central nervous system lymphomas. Population-based data from a Danish lymphoma registry. Danish Lymphoma Study Group, LYFO.

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12 December 2020

Methotrexate disposition following disruption of the blood-brain barrier.

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12 December 2020

CNS drug design based on principles of blood-brain barrier transport

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12 December 2020

Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor.

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12 December 2020

Vascular and interstitial barriers to delivery of therapeutic agents in tumors

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12 December 2020

Leptomeningeal metastases: rationale for systemic chemotherapy or what is the role of intra-CSF-chemotherapy?

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12 December 2020

Therapy of primary CNS lymphoma with methotrexate-based chemotherapy and deferred radiotherapy: preliminary results

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12 December 2020

In vitro and animal studies of sodium thiosulfate as a potential chemoprotectant against carboplatin-induced ototoxicity

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12 December 2020

Alteration of blood-brain-CSF barrier in experimental meningeal carcinomatosis. A morphologic and adriamycin-penetration study

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12 December 2020

Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications

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12 December 2020

High-dose methotrexate for the treatment of primary cerebral lymphomas: analysis of survival and late neurologic toxicity in a retrospective series

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12 December 2020

Temozolomide and treatment of malignant glioma.

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12 December 2020

High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary?

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12 December 2020

Phase II trial of chemotherapy alone for primary CNS and intraocular lymphoma

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12 December 2020

Primary intracerebral malignant lymphoma: report of 248 cases

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12 December 2020

Utility of relative cerebral blood volume mapping derived from perfusion magnetic resonance imaging in the routine follow up of brain tumors

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12 December 2020

Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

1 reference

12 December 2020

Enhanced delivery of boronophenylalanine for neutron capture therapy of brain tumors using the bradykinin analog Cereport (Receptor-Mediated Permeabilizer-7).

1 reference

12 December 2020

Modulation of blood-brain barrier permeability

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12 December 2020

Intravenous methotrexate as initial treatment for primary central nervous system lymphoma: response to therapy and quality of life of patients

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12 December 2020

Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis

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12 December 2020

Nonenhancing primary central nervous system lymphoma

1 reference

12 December 2020

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

1 reference

12 December 2020

Hyperosmolar blood-brain barrier disruption in baboons: an in vivo study using positron emission tomography and rubidium-82.

1 reference

12 December 2020

Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma. RMP-7 European Study Group.

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12 December 2020

Sites of origin of primary intracerebral malignant lymphoma

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12 December 2020

Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging

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12 December 2020

Comparison of cytosine arabinoside delivery to rat brain by intravenous, intrathecal, intraventricular and intraparenchymal routes of administration

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12 December 2020

Primary central nervous system non-Hodgkin's lymphoma: survival advantages with combined initial therapy?

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12 December 2020

Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors.

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12 December 2020

A comparative study on the pharmacokinetics of methotrexate in a dose range of 0.5 g to 33.6 g/m2 in children with acute lymphoblastic leukemia.

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12 December 2020

Regulation of the movement of solutes across tight junctions

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12 December 2020

Intravenous cereport (RMP-7) modifies topographic uptake profile of carboplatin within rat glioma and brain surrounding tumor, elevates platinum levels, and enhances survival.

1 reference

12 December 2020

Drug delivery to the brain

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12 December 2020

Primary central nervous system non-Hodgkin's lymphoma (PCNSL): survival advantages with combined initial therapy? A final report of the North Central Cancer Treatment Group (NCCTG) Study 86-72-52.

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12 December 2020

Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog.

1 reference

12 December 2020

Pharmacology and toxicity of intracarotid adriamycin administration following osmotic blood-brain barrier modification.

1 reference

12 December 2020

P-Glycoprotein, a gatekeeper in the blood-brain barrier

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12 December 2020

Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time

1 reference

12 December 2020

In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans.

1 reference

12 December 2020

Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis

1 reference

12 December 2020

Leptomeningeal tumor in primarchy central nervous system lymphoma: Recognition, significance, and implications

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12 December 2020

Comparison of 14C-sucrose delivery to the brain by intravenous, intraventricular, and convection-enhanced intracerebral infusion

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12 December 2020

Treatment for primary CNS lymphoma: the next step

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12 December 2020

Decreased delivery and acute toxicity of cranial irradiation and chemotherapy given with osmotic blood-brain barrier disruption in a rodent model: the issue of sequence.

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12 December 2020

Pharmacokinetics of methotrexate in cerebrospinal fluid and serum after osmotic blood-brain barrier disruption in patients with brain lymphoma.

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12 December 2020

Differential permeability of the blood-tumour barrier in intracerebral tumour-bearing rats: antidrug antibody to achieve systemic drug rescue

1 reference

12 December 2020

Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: Prolonged remission with the ommaya reservoir

1 reference

12 December 2020

Leptomeningeal metastases: evaluation by gadolinium enhanced spinal magnetic resonance imaging

1 reference

12 December 2020

Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration

1 reference

12 December 2020

Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas

1 reference

12 December 2020

Differential permeability of a human brain tumor xenograft in the nude rat: impact of tumor size and method of administration on optimizing delivery of biologically diverse agents

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12 December 2020

Model for drug uptake by brain tumors: effects of osmotic treatment and of diffusion in brain

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12 December 2020

10.2165/00003088-200241030-00002

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

1007844296

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