(Q34585359)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

author name string

C D Hurst

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

S V Williams

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

F M Platt

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

M A Knowles

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

language of work or name

English

0 references

publication date

26 November 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

page(s)

2716-2727

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

issue

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.onc.1210934

27 December 2019

exact match

0 references

cites work

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

7 July 2018

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

7 July 2018

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

7 July 2018

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Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Role of E2F3 expression in modulating cellular proliferation rate in human bladder and prostate cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway

7 July 2018

1 reference

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SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization

7 July 2018

1 reference

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Bladder cancer stage and outcome by array-based comparative genomic hybridization

7 July 2018

1 reference

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Expression analysis of 6p22 genomic gain in retinoblastoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

The E2F transcriptional network: old acquaintances with new faces

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Hitting their targets: an emerging picture of E2F and cell cycle control

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

The emerging role of E2F-1 in the DNA damage response and checkpoint control

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Amplification and overexpression of E2F3 in human bladder cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Defining a 0.5-mb region of genomic gain on chromosome 6p22 in bladder cancer by quantitative-multiplex polymerase chain reaction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Sibling rivalry in the E2F family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Functional antagonism between E2F family members

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Delineation of the 6p22 amplification unit in urinary bladder carcinoma cell lines.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

E2f3 is critical for normal cellular proliferation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

7 July 2018

1 reference

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The regulation of E2F by pRB-family proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Distinct roles for E2F proteins in cell growth control and apoptosis

7 July 2018

1 reference

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The retinoblastoma protein binds to a family of E2F transcription factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Characterization of human uroepithelial cells immortalized in vitro by simian virus 40.

7 July 2018

1 reference

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Altered Expression of Retinoblastoma Protein and Known Prognostic Variables in Locally Advanced Bladder Cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Altered expression of the retinoblastoma gene product: prognostic indicator in bladder cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency, a high frequency of homozygous co-deletion and associations with clinical phenotype.

7 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

Hyperphosphorylation of pRb: a mechanism for RB tumour suppressor pathway inactivation in bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

Nuclear overexpression of the E2F3 transcription factor in human lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

Lectins as probes for identification of tumor-associated antigens on urothelial and colonic carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

E2F3a stimulates proliferation, p53-independent apoptosis and carcinogenesis in a transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210934

Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2387074

Detection of chromosomal imbalances in papillary bladder tumors by comparative genomic hybridization

27 October 2018

1 reference

12 December 2020

Molecular cytogenetic alterations associated with rapid tumor cell proliferation in advanced urinary bladder cancer

1 reference

12 December 2020

Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression

1 reference

12 December 2020

Increased p16 levels correlate with pRb alterations in human urothelial cells

1 reference

12 December 2020

Chromosomal changes during progression of transitional cell carcinoma of the bladder and delineation of the amplified interval on chromosome arm 8q

1 reference

12 December 2020

Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer

1 reference

12 December 2020

E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.ONC.1210934

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

27 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18037967%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference