(Q34599695)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

A role of kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axis (English)

1 reference

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24 February 2020

4

1 reference

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24 February 2020

author name string

Zhi-Hong Xue

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Chen Feng

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Wei-Ling Liu

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

language of work or name

English

0 references

publication date

20 February 2013

1 reference

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24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

e56911

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

24 February 2020

copyright license

start time

20 February 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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7 July 2018

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Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1).

7 July 2018

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A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.

7 July 2018

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Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation

7 July 2018

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Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation

7 July 2018

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Mediation of Rac1 activation by kindlin-2: an essential function in osteoblast adhesion, spreading, and proliferation

7 July 2018

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Integrin structure, activation, and interactions

7 July 2018

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Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins

7 July 2018

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Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

7 July 2018

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The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell

7 July 2018

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Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

7 July 2018

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The final steps of integrin activation: the end game

7 July 2018

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Kindlins in FERM adhesion.

7 July 2018

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The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

7 July 2018

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The Kindlin protein family: new members to the club of focal adhesion proteins

7 July 2018

1 reference

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Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes

7 July 2018

1 reference

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Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions

7 July 2018

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The tail of integrins, talin, and kindlins

7 July 2018

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Adhesion signaling - crosstalk between integrins, Src and Rho.

7 July 2018

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Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

7 July 2018

1 reference

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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

7 July 2018

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Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

7 July 2018

1 reference

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A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

7 July 2018

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The mechanical integrin cycle.

7 July 2018

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Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function

7 July 2018

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Kindlin-2 controls bidirectional signaling of integrins

7 July 2018

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Intercellular adhesion molecule-3 binding of integrin alphaL beta2 requires both extension and opening of the integrin headpiece

7 July 2018

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Kindlin-3 is essential for integrin activation and platelet aggregation

7 July 2018

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Structure and mechanics of integrin-based cell adhesion.

7 July 2018

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Filopodia: the fingers that do the walking

7 July 2018

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RACK1 regulates Src activity and modulates paxillin dynamics during cell migration

7 July 2018

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Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3.

7 July 2018

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An essential role for talin during alpha(M)beta(2)-mediated phagocytosis

7 July 2018

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Structural basis of integrin regulation and signaling

7 July 2018

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

7 July 2018

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Down-regulation of integrin alpha M beta 2 ligand-binding function by the urokinase-type plasminogen activator receptor

7 July 2018

1 reference

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FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling

7 July 2018

1 reference

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The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function

7 July 2018

1 reference

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Rho GTPases: biochemistry and biology

7 July 2018

1 reference

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Neutrophil beta2 integrins: moderators of life or death decisions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers

7 July 2018

1 reference

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The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment

7 July 2018

1 reference

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Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

7 July 2018

1 reference

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Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Redox-dependent downregulation of Rho by Rac.

7 July 2018

1 reference

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RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Integrins: bidirectional, allosteric signaling machines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Regulatory and signaling properties of the Vav family

7 July 2018

1 reference

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7 July 2018

Signaling to Rho GTPases

1 reference

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Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration

7 July 2018

1 reference

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Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats.

7 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

7 July 2018

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056911

KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA-1- and CR3-dependent adhesion

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)

7 July 2018

1 reference

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Structure and function of leukocyte integrins

7 July 2018

2 references

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7 July 2018

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

Mac-1: a macrophage differentiation antigen identified by monoclonal antibody

7 July 2018

1 reference

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Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols.

7 July 2018

1 reference

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Integrin alphaMbeta2 clustering triggers phosphorylation and activation of protein kinase C delta that regulates transcription factor Foxp1 expression in monocytes

21 January 2018

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21 January 2018

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Kindlin-3: a new gene involved in the pathogenesis of LAD-III.

21 January 2018

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Modulation of CD11b/CD18 adhesive activity by its extracellular, membrane-proximal regions

21 January 2018

1 reference

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Syk is required for integrin signaling in neutrophils

21 January 2018

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Ligand-dependent activation of integrin alpha vbeta 3.

21 January 2018

1 reference

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Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3577682

The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration

26 October 2018

1 reference

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Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen

21 January 2018

1 reference

12 December 2020

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1 reference

12 December 2020

A catch to integrin activation

1 reference

12 December 2020

1 reference

12 December 2020

Effect of integrin beta 2 subunit truncations on LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) assembly, surface expression, and function

1 reference

12 December 2020

Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0056911

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

23437269

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23437269%20AND%20SRC:MED&resulttype=core&format=json