(Q34608704)

3 August 2017

1 reference

title

Transgenic systems in drug discovery: from target identification to humanized mice (English)

1 reference

3 August 2017

1 reference

Jan Törnell

1

1 reference

PubMed ID

11965395

3 August 2017

Michael Snaith

series ordinal

2

1 reference

3 August 2017

1 April 2002

1 reference

3 August 2017

1 reference

3 August 2017

7

1 reference

3 August 2017

461-470

1 reference

3 August 2017

8

1 reference

Genetic transformation of mouse embryos by microinjection of purified DNA

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Integration and Stable Germ Line Transmission of Genes Injected into Mouse Pronuclei

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Animal models of neuroimmune interactions in inflammatory diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Developmental roles of platelet-derived growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Overview and perspective on the therapy of Alzheimer's disease from a preclinical viewpoint

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Transgenic mouse models in angiogenesis and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

The application of high-throughput screening to novel lead discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

DNA microarrays in drug discovery and development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Genomics, gene expression and DNA arrays

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Proteomics to study genes and genomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Microarrays: lost in a storm of data?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

BRCA1 mutations in primary breast and ovarian carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A mouse phenome project

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Of mice and men: genetic skin diseases of keratin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Inducible and reversible gene expression with the rtTA system for the study of memory.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A versatile synthetic dimerizer for the regulation of protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

EPS8 and E3B1 transduce signals from Ras to Rac

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Site-specific recombination: developments and applications

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

An Escherichia coli system for assay of F1p site-specific recombination on substrate plasmids.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Recombinase-mediated gene activation and site-specific integration in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Inducible gene targeting in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Site- and time-specific gene targeting in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A causal role for E-cadherin in the transition from adenoma to carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Essential role for oncogenic Ras in tumour maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

A transgenic mouse expressing human CYP4B1 in the liver

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Role of CYP2E1 in the hepatotoxicity of acetaminophen

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Using genetic mutations to study the neural basis of behavior.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902234-1

7 January 2021

10.1016/S1359-6446(02)02234-1

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11965395