(Q34612242)

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

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author name string

Linda M Rorick-Kehn

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Bryan G Johnson

2

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3 August 2017

Karen M Knitowski

3

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Europe PubMed Central

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3 August 2017

Craig R Salhoff

4

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Europe PubMed Central

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3 August 2017

Jeffrey M Witkin

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Kenneth W Perry

6

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Europe PubMed Central

PubMed publication ID

3 August 2017

Kelly I Griffey

7

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Joseph P Tizzano

8

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

James A Monn

9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

David L McKinzie

10

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3 August 2017

Darryle D Schoepp

11

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3 August 2017

publication date

24 March 2007

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3 August 2017

Psychopharmacology

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3 August 2017

193

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Europe PubMed Central

PubMed publication ID

3 August 2017

1

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Europe PubMed Central

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3 August 2017

121-136

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Europe PubMed Central

PubMed publication ID

3 August 2017

Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacotherapy of generalized anxiety disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

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Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate II receptor agonists in panic disorder: a double blind clinical trial with LY354740.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of diazepam, citalopram, methadone and naloxone on PCP-induced stereotyped behaviour and social isolation in the rat social interaction test.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamatergic neurotransmission modulators as emerging new drugs for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxyli

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neurotransmitter release by metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antipsychotic action of selective group II metabotropic glutamate receptor agonist MGS0008 and MGS0028 on conditioned avoidance responses in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroleptic-induced movement disorders: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PCP: from pharmacology to modelling schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adverse effects of benzodiazepines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disposition, metabolism, and pharmacokinetics of a selective metabotropic glutamate receptor agonist in rats and dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740 affects startle responding but not sensorimotor gating or discriminative effects of phencyclidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of atypical antipsychotics and phencyclidine (PCP) on rotorod performance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of c-Fos induction in the brain by the mGlu2/3 receptor antagonist LY341495 and agonist LY354740: evidence for widespread endogenous tone at brain mGlu2/3 receptors in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and anxiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potent, selective mGlu2/3 receptor agonist LY379268 increases extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole-3-acetic acid in the medial prefrontal cortex of the freely moving rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weight gain as a prognostic indicator of therapeutic improvement during acute treatment of schizophrenia with placebo or active antipsychotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17384937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-007-0758-3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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