(Q34619663)

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Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

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Europe PubMed Central

PubMed publication ID

3 August 2017

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

Mycobacterium tuberculosis

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1 reference

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inferred from title

Escherichia coli

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inferred from title

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Gautham Shenoy

3

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Clifton E Barry

object named as

Clifton E Barry

14

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author name string

Pilho Kim

1

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3 August 2017

Yong-Mei Zhang

2

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3 August 2017

Quynh-Anh Nguyen

4

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3 August 2017

Helena I Boshoff

5

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3 August 2017

Ujjini H Manjunatha

6

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3 August 2017

Michael B Goodwin

7

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3 August 2017

John Lonsdale

8

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3 August 2017

Allen C Price

9

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3 August 2017

Darcie J Miller

10

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Europe PubMed Central

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3 August 2017

Ken Duncan

11

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Europe PubMed Central

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3 August 2017

Stephen W White

12

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3 August 2017

Charles O Rock

13

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3 August 2017

Cynthia S Dowd

15

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3 August 2017

language of work or name

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publication date

1 January 2006

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Europe PubMed Central

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3 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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3 August 2017

49

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Europe PubMed Central

PubMed publication ID

3 August 2017

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

159-171

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Europe PubMed Central

PubMed publication ID

3 August 2017

Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase.

1 reference

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Prospects for new antitubercular drugs

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

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Fatty acid biosynthesis as a target for novel antibacterials

1 reference

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Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

1 reference

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Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

1 reference

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Genes required for mycobacterial growth defined by high density mutagenesis

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1 reference

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Current medical treatment for tuberculosis

1 reference

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A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

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Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

1 reference

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7 July 2018

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis

1 reference

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Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum).

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis

1 reference

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Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli.

1 reference

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Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB

1 reference

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Thiolactomycin, a new antibiotic. III. In vitro antibacterial activity.

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

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7 July 2018

Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12

1 reference

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Accurate modeling of protein conformation by automatic segment matching

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Chemoselective construction of substituted conjugated dienes using an olefin cross-metathesis protocol

1 reference

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Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents

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Effect of thiolactomycin on the individual enzymes of the fatty acid synthase system in Escherichia coli

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Asymmetric synthesis of (-)-indolizidine 209D via B-alkyl Suzuki coupling and amination reactions

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Identifiers

10.1021/JM050825P

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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