(Q34623508)

3 August 2017

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title

A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis (English)

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3 August 2017

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L Scorrano

2

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author name string

L Pellegrini

series ordinal

1

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3 August 2017

publication date

20 April 2007

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Cell Death & Differentiation

3 August 2017

published in

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3 August 2017

volume

14

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3 August 2017

issue

7

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3 August 2017

page(s)

1275-1284

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402145

3 August 2017

exact match

0 references

cites work

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Cell signaling. H2O2, a necessary evil for cell signaling

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The pathophysiology of mitochondrial cell death

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7 January 2021

A mitochondrial perspective on cell death

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7 January 2021

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

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7 January 2021

The many shapes of mitochondrial death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The internal structure of mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

hFis1, a novel component of the mammalian mitochondrial fission machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

A human dynamin-related protein controls the distribution of mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Endophilin B1 is required for the maintenance of mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

OPA1 requires mitofusin 1 to promote mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mutation spectrum and splicing variants in the OPA1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Structural basis of mitochondrial tethering by mitofusin complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondria are redistributed in Drosophila photoreceptors lacking milton, a kinesin-associated protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Orchestration of lymphocyte chemotaxis by mitochondrial dynamics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondria, oxidants, and aging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Cell death: critical control points

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Rhomboid proteins: conserved membrane proteases with divergent biological functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Crystal structure of a rhomboid family intramembrane protease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

UGO1 encodes an outer membrane protein required for mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial processing peptidases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Studies on the regulation of the mitochondrial alpha-ketoacid dehydrogenase complexes and their kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Kinase signaling cascades in the mitochondrion: a matter of life or death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Mitochondrial signaling: the retrograde response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial dna mutant.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Characterization of peptides released from mitochondria: evidence for constant proteolysis and peptide efflux

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Evidence for a novel mitochondria-to-nucleus signalling pathway in respiring cells lacking i-AAA protease and the ABC-transporter Mdl1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402145

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402145

1 reference

3 August 2017

1 reference