(Q34625891)

14 June 2018

title

Metabolism, genotoxicity, and carcinogenicity of comfrey (English)

1 reference

14 June 2018

main subject

riddelliine

1 reference

ChEBI release 2020-05-28

1 reference

Nan Mei

1

1 reference

14 June 2018

Lei Guo

2

1 reference

14 June 2018

Peter P Fu

3

1 reference

14 June 2018

James C Fuscoe

4

1 reference

14 June 2018

Yang Luan

5

1 reference

14 June 2018

Tao Chen

6

1 reference

14 June 2018

language of work or name

1 reference

1 October 2010

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14 June 2018

Journal of Toxicology and Environmental Health Part B: Critical Reviews

published in

1 reference

14 June 2018

volume

13

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14 June 2018

issue

7-8

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14 June 2018

page(s)

509-526

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14 June 2018

Genotoxicity of pyrrolizidine alkaloids

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Comfrey (Symphytum Officinale. l.) and Experimental Hepatic Carcinogenesis: A Short-term Carcinogenesis Model Study

7 July 2018

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Influence of homeopathic treatment with comfrey on bone density around titanium implants: a digital subtraction radiography study in rats.

7 July 2018

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Some conservative strategies are effective when added to controlled mobilisation with external support after acute ankle sprain: a systematic review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Rat toxicogenomic study reveals analytical consistency across microarray platforms

7 July 2018

1 reference

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Mutagenicity of comfrey (Symphytum Officinale) in rat liver

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Workshop overview: Hepatotoxicity assessment for botanical dietary supplements

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Herbal bioactivation: the good, the bad and the ugly

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Honey from plants containing pyrrolizidine alkaloids: a potential threat to health.

7 July 2018

1 reference

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Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

The efficacy and safety of comfrey.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Pyrrolizidine alkaloids in human diet

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC-MS.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Analysis, separation, and bioassay of pyrrolizidine alkaloids from comfrey (Symphytum officinale).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Medicinal plants in Europe containing pyrrolizidine alkaloids.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Salmonella mutagenicity test results for 250 chemicals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Veno-occlusive disease of the liver secondary to ingestion of comfrey

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Comfrey: assessing the low-dose health risk.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Comfrey herb tea-induced hepatic veno-occlusive disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Isolation and identification of a pyrrolic glutathione conjugate metabolite of the pyrrolizidine alkaloid monocrotaline.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Hepatic veno-occlusive disease associated with comfrey ingestion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

The effects of comfrey derived pyrrolizidine alkaloids on rat liver.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Metabolism of [14C]monocrotaline by isolated perfused rat liver

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Structure/activity relationships of the genotoxic potencies of sixteen pyrrolizidine alkaloids assayed for the induction of somatic mutation and recombination in wing cells of Drosophila melanogaster.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Guinea pig and rat hepatic microsomal metabolism of monocrotaline

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Induction of hepatic tumors in rats by senkirkine and symphytine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Carcinogenic activity of Symphytum officinale

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Malignant neoplasms in rats fed lasiocarpine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Formation of DHP-derived DNA adducts in vivo from dietary supplements and chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids.

7 July 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Identification of DNA adducts derived from riddelliine, a carcinogenic pyrrolizidine alkaloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Determination of pyrrolizidine alkaloids in comfrey by liquid chromatography-electrospray ionization mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Comfrey toxicity revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Evaporative light scattering detection of pyrrolizidine alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

An evaluation of acetone extracts from six plants in the Ames mutagenicity test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Simultaneous analysis of hepatotoxic pyrrolizidine alkaloids and N-oxides in comfrey root by LC-ion trap mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10937404.2010.509013

Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Investigation of pyrrolizidine alkaloids and their N-oxides in commercial comfrey-containing products and botanical materials by liquid chromatography electrospray ionization mass spectrometry.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

A rapid cleanup method for the isolation and concentration of pyrrolizidine alkaloids in comfrey root.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5894094

Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid chromatography mass spectrometry with an electrospray interface

26 October 2018

1 reference

12 December 2020

Pyrrolizidine alkaloids from Symphytum officinale L. and their percutaneous absorption in rats

1 reference

12 December 2020

Hepatic venocclusive disease associated with the consumption of pyrrolizidine-containing dietary supplements

1 reference

12 December 2020

Mutagenic effects of aqueous extracts of Symphytum officinale L. and of its alkaloidal fractions

1 reference

12 December 2020

Bioassay of lasiocarpine for possible carcinogenicity

1 reference

12 December 2020

Hepatotoxicity due to comfrey herb tea

1 reference

12 December 2020

Comfrey and liver damage

1 reference

12 December 2020

Consumption of poisonous plants (Senecio jacobaea, Symphytum officinale, Pteridium aquilinum, Hypericum perforatum) by rats: chronic toxicity, mineral metabolism, and hepatic drug-metabolizing enzymes

1 reference

12 December 2020

[Studies on the effect of an alkaloid extract of Symphytum officinale on human lymphocyte cultures]

1 reference

12 December 2020

Comfrey herb tea and hepatic veno-occlusive disease

1 reference

12 December 2020

Chromosomal aberrations and mutation in cultured mammalian cells induced by pyrrolizidine alkaloids

1 reference

12 December 2020

Determination of pyrrolizidine alkaloids in commercial comfrey products (Symphytum sp.).

1 reference

12 December 2020

The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine

1 reference

12 December 2020

Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L

1 reference

12 December 2020

The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats

1 reference

12 December 2020

Malignant tumors in rats given lasiocarpine

1 reference

12 December 2020

Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid

1 reference

12 December 2020

Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study

1 reference

12 December 2020

Detection of pyrrolizidine alkaloids on thin-layer chromatograms

1 reference

12 December 2020

Toxicity of comfrey-pepsin preparations

1 reference

12 December 2020

Studies on Constituents of Crude Drugs. I. Alkaloids of Symphytum officinale LINN

1 reference

12 December 2020

10.1080/10937404.2010.509013

Identifiers

DOI

1 reference

14 June 2018

PMCID

5894094

1 reference

14 June 2018

PubMed ID

21170807

1 reference

14 June 2018