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Integrating signals from RTKs to ERK/MAPK.
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scholarly article
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Europe PubMed Central
PubMed ID
17496910
retrieved
3 August 2017
review article
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Europe PubMed Central
title
Integrating signals from RTKs to ERK/MAPK.
(English)
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Europe PubMed Central
PubMed ID
17496910
retrieved
3 August 2017
main subject
endosomal scaffold complex
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Gene Ontology release 2020-05-02
Gene Ontology ID
GO:0032969
author name string
McKay MM
series ordinal
1
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Europe PubMed Central
PubMed ID
17496910
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3 August 2017
Morrison DK
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2
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Europe PubMed Central
PubMed ID
17496910
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3 August 2017
language of work or name
English
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publication date
1 May 2007
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Europe PubMed Central
PubMed ID
17496910
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3 August 2017
published in
Oncogene
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Europe PubMed Central
PubMed ID
17496910
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3 August 2017
volume
26
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Europe PubMed Central
PubMed ID
17496910
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3 August 2017
page(s)
3113-3121
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Europe PubMed Central
PubMed ID
17496910
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3 August 2017
issue
22
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Europe PubMed Central
PubMed ID
17496910
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3 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1210394
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Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation
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Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling
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Compartmentalized signal transduction by receptor tyrosine kinases
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Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1
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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
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A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
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Regulation of ras signaling dynamics by Sos-mediated positive feedback
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Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.
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Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking
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7 January 2021
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Ras signalling on the endoplasmic reticulum and the Golgi
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7 January 2021
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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi
1 reference
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Crossref
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7 January 2021
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Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
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Murine Ksr interacts with MEK and inhibits Ras-induced transformation
1 reference
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Untying the regulation of the Raf-1 kinase
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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs
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Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.
1 reference
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reference URL
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7 January 2021
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A Ras-induced conformational switch in the Ras activator Son of sevenless
1 reference
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Crossref
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7 January 2021
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Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
1 reference
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7 January 2021
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Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway
1 reference
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Crossref
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7 January 2021
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Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty
1 reference
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Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
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7 January 2021
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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
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Erbin suppresses the MAP kinase pathway
1 reference
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Crossref
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7 January 2021
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Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
1 reference
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7 January 2021
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Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis
1 reference
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Crossref
reference URL
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based on heuristic
inferred from DOI database lookup
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways
1 reference
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reference URL
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7 January 2021
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Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho
1 reference
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7 January 2021
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Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
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Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells
1 reference
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Crossref
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7 January 2021
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Differential modification of Ras proteins by ubiquitination.
1 reference
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Crossref
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7 January 2021
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Identification of a putative Syp substrate, the PDGF beta receptor
1 reference
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Crossref
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7 January 2021
based on heuristic
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Coordinating ERK/MAPK signalling through scaffolds and inhibitors
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
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Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ras effectors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Compartmentalized Ras/MAPK signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Regulation and targets of receptor tyrosine kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ras signaling from plasma membrane and endomembrane microdomains
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation
1 reference
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7 January 2021
based on heuristic
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Germline gain-of-function mutations in SOS1 cause Noonan syndrome
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
1 reference
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reference URL
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7 January 2021
based on heuristic
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Regulation and role of Raf-1/B-Raf heterodimerization
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell signaling by receptor tyrosine kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural analysis of autoinhibition in the Ras activator Son of sevenless
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
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Signal transduction and endocytosis: close encounters of many kinds
1 reference
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reference URL
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7 January 2021
based on heuristic
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Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.
1 reference
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7 January 2021
based on heuristic
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p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sef is a spatial regulator for Ras/MAP kinase signaling.
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Spred is a Sprouty-related suppressor of Ras signalling
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
The RAF proteins take centre stage
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
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Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
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7 January 2021
based on heuristic
inferred from DOI database lookup
CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1210394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1210394
1 reference
stated in
Europe PubMed Central
PubMed ID
17496910
retrieved
3 August 2017
Dimensions Publication ID
1021376021
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PubMed ID
17496910
1 reference
stated in
Europe PubMed Central
PubMed ID
17496910
retrieved
3 August 2017
ResearchGate publication ID
6334934
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