(Q34770359)

4 August 2017

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title

Signal transduction and endocytosis: close encounters of many kinds (English)

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4 August 2017

Alexander Sorkin

1

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4 August 2017

Mark Von Zastrow

series ordinal

2

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4 August 2017

publication date

1 August 2002

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Nature Reviews Molecular Cell Biology

4 August 2017

published in

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4 August 2017

volume

3

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4 August 2017

issue

8

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4 August 2017

page(s)

600-614

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Cell signaling by receptor tyrosine kinases

4 August 2017

cites work

1 reference

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Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts

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Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes

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Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts

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Induction of mutant dynamin specifically blocks endocytic coated vesicle formation

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Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431

31 March 2020

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Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

31 March 2020

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Dual pathways of internalization of the cholecystokinin receptor

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Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization

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Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes

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Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

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Insulation of a G protein-coupled receptor on the plasmalemmal surface of the pancreatic acinar cell

31 March 2020

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Membrane transport in the endocytic pathway

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

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Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathways

31 March 2020

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Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

31 March 2020

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Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L-cells.

31 March 2020

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Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodies

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Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts

31 March 2020

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Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes

31 March 2020

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Ligand-induced transformation by a noninternalizing epidermal growth factor receptor

31 March 2020

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Downregulation of G protein-coupled receptors

31 March 2020

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Regulated endocytic routing modulates wingless signaling in Drosophila embryos.

31 March 2020

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Wingless gradient formation in the Drosophila wing

31 March 2020

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Gradient formation of the TGF-beta homolog Dpp.

31 March 2020

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Creation of a Sog morphogen gradient in the Drosophila embryo

31 March 2020

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Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

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Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

31 March 2020

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Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

31 March 2020

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The endocytosis of epidermal growth factor in A431 cells: a pH of microenvironment and the dynamics of receptor complex dissociation

31 March 2020

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Pool of ligand‐bound platelet‐derived growth factor β‐receptors remain activated and tyrosine phosphorylated after internalization

31 March 2020

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Nerve growth factor processing and trafficking events following TrkA-mediated endocytosis

31 March 2020

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Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction

31 March 2020

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Binding and processing of epidermal growth factor in Panc-I human pancreatic carcinoma cells

31 March 2020

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Compartmentalized signal transduction by receptor tyrosine kinases

31 March 2020

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Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes

31 March 2020

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The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity

31 March 2020

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Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor

31 March 2020

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Human VPS34 is required for internal vesicle formation within multivesicular endosomes

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Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila

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Agonist-dependent traffic of raft-associated Ras and Raf-1 is required for activation of the mitogen-activated protein kinase cascade

31 March 2020

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Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

31 March 2020

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

31 March 2020

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Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment

31 March 2020

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Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a

31 March 2020

1 reference

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway

31 March 2020

1 reference

Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase

31 March 2020

1 reference

A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment

31 March 2020

1 reference

Nerve growth factor activates persistent Rap1 signaling in endosomes

31 March 2020

1 reference

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

31 March 2020

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Lipid modifications and membrane targeting of G alpha

31 March 2020

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Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding

31 March 2020

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Arresting developments in heptahelical receptor signaling and regulation

31 March 2020

1 reference

Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization

31 March 2020

1 reference

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

31 March 2020

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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

31 March 2020

1 reference

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

31 March 2020

1 reference

Neurotrophins: roles in neuronal development and function

31 March 2020

1 reference

The retrograde axonal transport of nerve growth factor

31 March 2020

1 reference

NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway

31 March 2020

1 reference

An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons

31 March 2020

1 reference

Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.

31 March 2020

1 reference

Location, location, location: a spatial view of neurotrophin signal transduction

31 March 2020

1 reference

On Trk for retrograde signaling

31 March 2020

1 reference

Signal transduction by target-derived neurotrophins

31 March 2020

1 reference

Retrograde support of neuronal survival without retrograde transport of nerve growth factor

31 March 2020

1 reference

Control of EGF receptor signaling by clathrin-mediated endocytosis.

31 March 2020

1 reference

Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation

31 March 2020

1 reference

Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways

31 March 2020

1 reference

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.

31 March 2020

1 reference

The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

31 March 2020

1 reference

Epidermal growth factor receptor efficiently activates mitogen-activated protein kinase in HeLa cells and Hep2 cells conditionally defective in clathrin-dependent endocytosis

31 March 2020

1 reference

Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes

31 March 2020

1 reference

Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction

31 March 2020

1 reference

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

31 March 2020

1 reference

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

31 March 2020

1 reference

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

31 March 2020

1 reference

Beta-Arrestins: new roles in regulating heptahelical receptors' functions

31 March 2020

1 reference

Regulated endocytosis of G-protein-coupled receptors by a biochemically and functionally distinct subpopulation of clathrin-coated pits

31 March 2020

1 reference

Recruitment of activated G protein-coupled receptors to pre-existing clathrin-coated pits in living cells

31 March 2020

1 reference

G protein-coupled receptor/arrestin3 modulation of the endocytic machinery

31 March 2020

1 reference

Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP

31 March 2020

1 reference

NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.

31 March 2020

1 reference

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

31 March 2020

1 reference

Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis

31 March 2020

1 reference

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system

31 March 2020

1 reference

Distinct saturable pathways for the endocytosis of different tyrosine motifs

31 March 2020

1 reference

Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

31 March 2020

1 reference

Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

31 March 2020

1 reference

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

31 March 2020

1 reference

A new ticket for entry into budding vesicles-ubiquitin

31 March 2020

1 reference

Epidermal growth factor induces ubiquitination of Eps15.

31 March 2020

1 reference

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

31 March 2020

1 reference

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

31 March 2020

1 reference

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

31 March 2020

1 reference

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

31 March 2020

1 reference

Selective membrane protein trafficking: vectorial flow and filter

31 March 2020

1 reference

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

31 March 2020

1 reference

Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting

31 March 2020

1 reference

Lysosomal targeting of epidermal growth factor receptors via a kinase-dependent pathway is mediated by the receptor carboxyl-terminal residues 1022-1123.

31 March 2020

1 reference

Rab proteins as membrane organizers

31 March 2020

1 reference

Hrs recruits clathrin to early endosomes

31 March 2020

1 reference

Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain

31 March 2020

1 reference

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates

31 March 2020

1 reference

Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion

31 March 2020

1 reference

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

31 March 2020

1 reference

beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis

31 March 2020

1 reference

Imaging biochemistry inside cells

31 March 2020

1 reference

Fluorescence lifetime imaging of receptor tyrosine kinase activity in cells

31 March 2020

1 reference

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.

31 March 2020

1 reference

A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo.

31 March 2020

1 reference

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells

31 March 2020

1 reference

G-protein-coupled receptors function as oligomers in vivo

31 March 2020

1 reference

Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers

31 March 2020

1 reference

Receptor-mediated activation of heterotrimeric G-proteins in living cells

31 March 2020

1 reference

A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation

31 March 2020

1 reference

Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3.

31 March 2020

1 reference

G-protein-coupled receptors: turn-ons and turn-offs

31 March 2020

1 reference

A serine cluster prevents recycling of the V2 vasopressin receptor

31 March 2020

1 reference

Type-specific sorting of G protein-coupled receptors after endocytosis

31 March 2020

1 reference

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor

31 March 2020

1 reference

beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin

31 March 2020

1 reference

Notch signaling: cell fate control and signal integration in development

31 March 2020

1 reference

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex

31 March 2020

1 reference

Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

31 March 2020

1 reference

Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

31 March 2020

1 reference

Enhanced degradation of EGF receptors by a sorting nexin, SNX1

31 March 2020

1 reference

A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors

31 March 2020

1 reference

SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P

31 March 2020

1 reference

Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking

31 March 2020

1 reference

EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes.

31 March 2020

1 reference

Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor

31 March 2020

1 reference

Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton

31 March 2020

1 reference

RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking

31 March 2020

1 reference

Association of p60c-src with endosomal membranes in mammalian fibroblasts

31 March 2020

1 reference

Mechanisms of β-Adrenergic Receptor Desensitization and Resensitization

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM883

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Dimensions Publication ID

4 August 2017

1033108369

0 references

1 reference