(Q34629933)

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6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1 (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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1 reference

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lymphoblastic leukemia

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Bifeng Yuan

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Europe PubMed Central

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3 August 2017

author name string

Jing Zhang

2

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3 August 2017

Hongxia Wang

3

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3 August 2017

Lei Xiong

4

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3 August 2017

Qian Cai

5

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Europe PubMed Central

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3 August 2017

Tina Wang

6

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Europe PubMed Central

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3 August 2017

Steven Jacobsen

7

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Europe PubMed Central

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3 August 2017

Sriharsa Pradhan

8

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3 August 2017

Yinsheng Wang

9

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3 August 2017

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publication date

14 January 2011

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3 August 2017

Cancer Research

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3 August 2017

71

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3 August 2017

5

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3 August 2017

1904-1911

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Europe PubMed Central

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3 August 2017

6-Thioguanine and S⁶-methylthioguanine are mutagenic in human cells

1 reference

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7 July 2018

LC-MS/MS coupled with stable isotope dilution method for the quantification of 6-thioguanine and S(6)-methylthioguanine in genomic DNA of human cancer cells treated with 6-thioguanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Increased CXCR4 expression in AsPC1 pancreatic carcinoma cells with RNA interference-mediated knockdown of DNMT1 and DNMT3B.

1 reference

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7 July 2018

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

1 reference

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7 July 2018

Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.

1 reference

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The effect of thiopurine drugs on DNA methylation in relation to TPMT expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine, and guanine-S6-sulfonic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

DNA methylation and human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

1 reference

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7 July 2018

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

DNA methylation 40 years later: Its role in human health and disease

1 reference

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Netrin-1 and its receptors in tumorigenesis

1 reference

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The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes

1 reference

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Gene silencing in cancer in association with promoter hypermethylation

1 reference

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Prolonged survival of human-kidney homografts by immunosuppressive drug therapy

1 reference

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7 July 2018

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

DNA methylation patterns and epigenetic memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

A novel protein complex distinct from mismatch repair binds thioguanylated DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Genomic organization of a new candidate tumor suppressor gene, LRP1B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

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Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

Suppression of intestinal neoplasia by DNA hypomethylation.

1 reference

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Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

7 July 2018

The purine path to chemotherapy

1 reference

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Improving the curability of acute leukemia: pharmacologic approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

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Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

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A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

26 October 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049985

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21239472

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DNA methylation properties: consequences for pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/21239472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA methylation in malignant MOLT F4 lymphoblasts by 6-mercaptopurine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21239472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21239472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21239472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute lymphoblastic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21239472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21239472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-10-3430

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Europe PubMed Central

PubMed publication ID

3 August 2017

release_2cueuiqnonfqlez24czqdhs4zq

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https://api.fatcat.wiki/v0/release/2cueuiqnonfqlez24czqdhs4zq

24 November 2022

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Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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