(Q34633315)

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

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Europe PubMed Central

PubMed publication ID

3 August 2017

TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

ChEBI release 2020-05-28

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Tefferi A

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Europe PubMed Central

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3 August 2017

author name string

Pardanani A

1

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Europe PubMed Central

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3 August 2017

Hood J

2

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Europe PubMed Central

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3 August 2017

Lasho T

3

1 reference

Europe PubMed Central

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3 August 2017

Levine RL

4

1 reference

Europe PubMed Central

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3 August 2017

Martin MB

5

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Europe PubMed Central

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3 August 2017

Noronha G

6

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Europe PubMed Central

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3 August 2017

Finke C

7

1 reference

Europe PubMed Central

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3 August 2017

Mak CC

8

1 reference

Europe PubMed Central

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3 August 2017

Mesa R

9

1 reference

Europe PubMed Central

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3 August 2017

Zhu H

10

1 reference

Europe PubMed Central

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3 August 2017

Soll R

11

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Europe PubMed Central

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3 August 2017

Gilliland DG

12

1 reference

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3 August 2017

language of work or name

1 reference

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publication date

31 May 2007

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Europe PubMed Central

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3 August 2017

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Europe PubMed Central

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3 August 2017

21

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3 August 2017

8

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3 August 2017

1658-1668

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3 August 2017

Oncogenes in myeloproliferative disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of a new JAK2 D620E mutation in addition to V617F in a patient with polycythemia vera

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: an Olmsted County Study, 1976-1995.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation studies in CD3+, CD19+ and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating alleles of JAK3 in acute megakaryoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

JAK2 mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404750

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2404750

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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