(Q35849213)

English

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

scientific article published on 27 June 2006

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

based on heuristic

inferred from title

object named as

Thomas Mercher

1

0 references

10

object named as

Titus J Boggon

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

author name string

Gerlinde Wernig

2

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Europe PubMed Central

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10 August 2017

Sandra A Moore

3

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Europe PubMed Central

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10 August 2017

Ross L Levine

4

1 reference

Europe PubMed Central

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10 August 2017

Ting-Lei Gu

5

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Europe PubMed Central

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10 August 2017

Stefan Fröhling

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Dana Cullen

7

1 reference

Europe PubMed Central

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10 August 2017

Roberto D Polakiewicz

8

1 reference

Europe PubMed Central

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10 August 2017

Olivier A Bernard

9

1 reference

Europe PubMed Central

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10 August 2017

Benjamin H Lee

11

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Europe PubMed Central

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10 August 2017

D Gary Gilliland

12

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Europe PubMed Central

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10 August 2017

language of work or name

0 references

publication date

27 June 2006

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

108

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Europe PubMed Central

PMC publication ID

10 August 2017

8

1 reference

Europe PubMed Central

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10 August 2017

2770-2779

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

A gain-of-function mutation of JAK2 in myeloproliferative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

GATA1 in normal and malignant hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

The role of FLT3 in haematopoietic malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Signal transducer and activator of transcription proteins in leukemias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Constitutive activation of STAT transcription factors in acute myelogenous leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Congenital acute megakaryoblastic leukemia (M7) with chromosomal t(1;22)(p13;q13) translocation in a set of identical twins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

The enigmatic megakaryocyte gradually reveals its secrets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

A low affinity chimeric human alpha/beta-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

In vitro establishment and characterization of a human megakaryoblastic cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Cytogenetic findings in adult acute leukemia and myeloproliferative disorders with an involvement of megakaryocyte lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

Leukemia in Down syndrome: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

11 July 2018

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

24 September 2018

Signal transduction by several KIT juxtamembrane domain mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

24 September 2018

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

24 September 2018

Acute Megakaryoblastic Leukaemia: A National Clinical and Biological Study of 53 Adult and Childhood Cases by the Groupe Français d'Hématologie Cellulaire (GFHC)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895587

24 September 2018

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute megakaryocytic leukemia in essential thrombocythemia: an unusual evolution?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosome 19 abnormalities are commonly seen in AML, M7

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological study of in vitro maturation of human megakaryocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Megakaryoblastic leukemia in an infant. Establishment of a megakaryocytic tumor cell line in athymic nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloproliferative disorders terminating in acute megakaryoblastic leukemia with chromosome 3q26 abnormality

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2006-04-014712

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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