(Q34635580)

3 August 2017

title

{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE. (English)

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3 August 2017

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Ye Ingrid Yin

1

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3 August 2017

Bhramdeo Bassit

2

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3 August 2017

Lei Zhu

3

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3 August 2017

Xia Yang

4

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3 August 2017

Chunyu Wang

5

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3 August 2017

Yue-Ming Li

6

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3 August 2017

language of work or name

English

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publication date

7 June 2007

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Journal of Biological Chemistry

3 August 2017

number of pages

6

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based on heuristic

inferred from page(s)

published in

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3 August 2017

volume

282

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3 August 2017

issue

32

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3 August 2017

page(s)

23639-23644

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

3 August 2017

cites work

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The C-terminus of the beta protein is critical in amyloidogenesis

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Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

21 January 2018

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

21 January 2018

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Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

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Abeta40 inhibits amyloid deposition in vivo.

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

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Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

21 January 2018

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Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

21 January 2018

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Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

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Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

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The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

21 January 2018

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Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

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PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein

21 January 2018

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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

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Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704601200

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

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Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M704601200

1 reference

3 August 2017

1 reference