(Q24292718)

GOA release 2020-03-11

enzyme binding

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

author name string

Jun Xie

series ordinal

1

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Qing Guo

series ordinal

2

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language of work or name

English

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publication date

8 April 2005

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published in

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volume

280

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issue

14

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page(s)

13824-32

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cites work

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

21 January 2018

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Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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The presenilins in Alzheimer's disease--proteolysis holds the key.

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Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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Specific transcellular binding between membrane proteins crucial to Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411933200

Cellular mechanisms of beta-amyloid production and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The Role of presenilins in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Study of Memapsin 2 (β-Secretase) and Strategy of Inhibitor Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Enzymic properties of recombinant BACE2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Secretases as therapeutic targets for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Inhibition of BACE, a promising approach to Alzheimer's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

BACE1: the beta-secretase enzyme in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Memapsin 2 (beta-secretase) as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

gamma-Secretase: characterization and implication for Alzheimer disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The search for gamma-secretase and development of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

In search of gamma-secretase: presenilin at the cutting edge

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Neuroscience. An accomplice for gamma-secretase brought into focus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Alzheimer's disease. In search of gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Specificity of the Alzheimer's amyloid precursor protein α-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

alpha- and beta-secretase: profound changes in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Identification of novel transcription factor-like gene from human intestinal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

AATF protects neural cells against oxidative damage induced by amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Expression and function of the leucine zipper protein Par-4 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

7 January 2021

Memapsin 2, a drug target for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

7 January 2021

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411933200

7 January 2021