(Q44241753)

1 December 2017

gamma-Secretase: characterization and implication for Alzheimer disease therapy (English)

1 reference

1 December 2017

0 references

Min Xu

1

1 reference

1 December 2017

Ming-Tain Lai

2

1 reference

1 December 2017

Qian Huang

3

1 reference

1 December 2017

Jillian DiMuzio-Mower

4

1 reference

1 December 2017

José L Castro

5

1 reference

1 December 2017

Timothy Harrison

6

1 reference

1 December 2017

Alan Nadin

7

1 reference

1 December 2017

Joseph G Neduvelil

8

1 reference

1 December 2017

Mark S Shearman

9

1 reference

1 December 2017

Jules A Shafer

10

1 reference

1 December 2017

Stephen J Gardell

11

1 reference

1 December 2017

Yue-Ming Li

12

1 reference

1 December 2017

1 November 2002

1 reference

1 December 2017

Neurobiology of Aging

1 reference

1 December 2017

23

1 reference

1 December 2017

6

1 reference

1 December 2017

1023-1030

1 reference

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Presenilin-dependent gamma-secretase activity modulates thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Presenilin-dependent gamma-secretase activity modulates neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Gamma -secretase inhibitors repress thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Mapping peptide-binding domains of the substance P (NK-1) receptor from P388D1 cells with photolabile agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Gamma-secretase: never more enigmatic

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900126-4

7 January 2021

10.1016/S0197-4580(02)00126-4

Identifiers

DOI

1 reference

1 December 2017

1 reference