(Q34641729)

3 August 2017

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title

Calcineurin and cardiac hypertrophy: where have we been? Where are we going? (English)

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3 August 2017

Jeffery D Molkentin

2

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author name string

Benjamin J Wilkins

series ordinal

1

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3 August 2017

language of work or name

English

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publication date

1 May 2002

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3 August 2017

published in

Journal of Physiology

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3 August 2017

volume

541

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3 August 2017

issue

Pt 1

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3 August 2017

page(s)

1-8

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Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Cardiac-muscle hypertrophy. Differentiation and growth of the heart cell during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT

21 January 2018

2 references

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290305

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

18 November 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Ras regulates NFAT3 activity in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin and human heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Cardiac hypertrophy: sorting out the circuitry

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calreticulin is essential for cardiac development

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin and beyond: cardiac hypertrophic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Cytoplasmic signaling pathways that regulate cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin-GATA4 pathway is involved in beta-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

General cardiology: The athlete's heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

The transcription factor NF-ATc is essential for cardiac valve formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Transcription factors of the NFAT family: regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Electrical remodeling in pressure-overload cardiac hypertrophy: role of calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Na+-Ca2+ exchanger remodeling in pressure overload cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin, Mitochondrial Membrane Potential, and Cardiomyocyte Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Loss of connexin45 causes a cushion defect in early cardiogenesis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290305

The transcription factor NFAT4 is involved in the generation and survival of T cells

18 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290305

Consequences of weight cycling in obese spontaneously hypertensive rats

18 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290305

Sites of protein conservation and loss during starvation: influence of adiposity.

18 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290305

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

18 November 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2002.017129

Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy

21 January 2018

1 reference

12 December 2020

Calcineurin inhibitors and cardiac hypertrophy

1 reference

12 December 2020

Cardiac atrophy in the heterotopically transplanted rat heart: in vitro protein synthesis

1 reference

12 December 2020

Calcineurin inhibitors and cardiac hypertrophy

1 reference

12 December 2020

Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure

1 reference

12 December 2020

Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats

1 reference

12 December 2020

Reply to revisiting calcineurin and human heart failure

1 reference

12 December 2020

Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy

1 reference

12 December 2020

Revisiting calcineurin and human heart failure

1 reference

12 December 2020

Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats

1 reference

12 December 2020

Many pathways to cardiac hypertrophy

1 reference

12 December 2020

Calcineurin blockade prevents cardiac mitogen-activated protein kinase activation and hypertrophy in renovascular hypertension

1 reference

12 December 2020

Cardiac hypertrophy is not a required compensatory response to short-term pressure overload

1 reference

12 December 2020

Cyclosporin A treatment alters characteristics of Ca2+-release channel in cardiac sarcoplasmic reticulum

1 reference

12 December 2020

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

1 reference

12 December 2020

Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles

1 reference

12 December 2020

Pressure Overload Induces Severe Hypertrophy in Mice Treated With Cyclosporine, an Inhibitor of Calcineurin

1 reference

12 December 2020

Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension

1 reference

12 December 2020

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1 reference

12 December 2020

10.1113/JPHYSIOL.2002.017129

Identifiers

DOI

1 reference

3 August 2017

0 references

1 reference