(Q34646728)

English

PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2 (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

phosphorylation

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author name string

Jeong Goo Lee

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

EunDuck P Kay

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

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publication date

21 January 2011

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Investigative Ophthalmology Visual Science

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

52

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

417-426

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Induction of FGF-2 synthesis by IL-1beta in aqueous humor through P13-kinase and p38 in rabbit corneal endothelium

1 reference

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Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer

1 reference

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The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest

1 reference

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Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

1 reference

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Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex

1 reference

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Joint requirement for Rac and ERK activities underlies the mid-G1 phase induction of cyclin D1 and S phase entry in both epithelial and mesenchymal cells

1 reference

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7 July 2018

The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway

1 reference

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Temporal-spatial expressions of p27kip1 and its phosphorylation on Serine-10 after acute spinal cord injury in adult rat: Implications for post-traumatic glial proliferation

1 reference

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H32, a non-quinone sulfone analog of vitamin K3, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK.

1 reference

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Regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation

1 reference

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Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.

1 reference

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Cdc25A and ERK interaction: EGFR-independent ERK activation by a protein phosphatase Cdc25A inhibitor, compound 5.

1 reference

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HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways

1 reference

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

1 reference

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7 July 2018

Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

7 July 2018

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

7 July 2018

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

7 July 2018

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

7 July 2018

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

7 July 2018

Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

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Phosphatidylinositol 3-kinases in tumor progression

1 reference

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Extracellular matrix components in retrocorneal fibrous membrane in comparison to corneal endothelium and Descemet's membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

7 July 2018

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

7 July 2018

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053288

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Corneal endothelial modulation: bFGF as direct mediator and corneal endothelium modulation factor as inducer

1 reference

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1 reference

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The PI3K/Akt/FOXO3a/p27Kip1 signaling contributes to anti-inflammatory drug-suppressed proliferation of human osteoblasts.

1 reference

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Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells.

1 reference

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Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor.

1 reference

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Common and distinct pathways for cellular activities in FGF-2 signaling induced by IL-1beta in corneal endothelial cells

1 reference

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Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells

1 reference

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26 October 2018

Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation

1 reference

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26 October 2018

Cross-talk among Rho GTPases acting downstream of PI 3-kinase induces mesenchymal transformation of corneal endothelial cells mediated by FGF-2.

1 reference

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FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the phosphatidylinositol 3-kinase pathway

1 reference

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1 reference

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1 reference

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Expression of cell cycle-associated proteins in human and rabbit corneal endothelium in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/20811053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle kinetics in corneal endothelium from old and young donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20811053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type I collagen and fibronectin synthesis by retrocorneal fibrous membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/20811053

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based on heuristic

inferred from PubMed ID database lookup

Characterization of fibrous retrocorneal membrane by confocal microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20811053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1167/IOVS.10-6140

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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