(Q34648294)

3 August 2017

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title

Looking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level (English)

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3 August 2017

A L Hughes

1

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PubMed ID

17622265

3 August 2017

language of work or name

English

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publication date

11 July 2007

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3 August 2017

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3 August 2017

99

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3 August 2017

364-373

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3 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.hdy.6801031

3 August 2017

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cites work

Bmp4 and Morphological Variation of Beaks in Darwin's Finches

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Adaptive evolution of non-coding DNA in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Natural selection on protein-coding genes in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

The cost of inbreeding in Arabidopsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Large-scale search for genes on which positive selection may operate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Does nonneutral evolution shape observed patterns of DNA variation in animal mitochondrial genomes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Natural selection on gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Neutral mutation hypothesis test

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Genetic traces of ancient demography

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

The locus of evolution: evo devo and the genetics of adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

A single amino acid mutation contributes to adaptive beach mouse color pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Evidence for abundant slightly deleterious polymorphisms in bacterial populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Micro-scale signature of purifying selection in Marburg virus genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Coding sequence polymorphism in avian mitochondrial genomes reflects population histories

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Natural selection on the peptide-binding regions of major histocompatibility complex molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Natural selection at the class II major histocompatibility complex loci of mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Widespread purifying selection at polymorphic sites in human protein-coding loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Simultaneous positive and purifying selection on overlapping reading frames of the tat and vpr genes of simian immunodeficiency virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Genomic signatures of positive selection in humans and the limits of outlier approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Evolution of primate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Toward a neutral evolutionary model of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

SOLUTION OF A PROCESS OF RANDOM GENETIC DRIFT WITH A CONTINUOUS MODEL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Evolutionary Rate at the Molecular Level

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Evolution at two levels in humans and chimpanzees

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Adaptive protein evolution at the Adh locus in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Adaptations to fluctuating selection in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

The genetic basis of adaptive melanism in pocket mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Slightly Deleterious Mutant Substitutions in Evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Role of very slightly deleterious mutations in molecular evolution and polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Amino acid substitution at the Adh locus of Drosophila is facilitated by small population size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Near-neutrality in evolution of genes and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Population genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Adaptive genic evolution in the Drosophila genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Adaptive protein evolution in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Higher intensity of purifying selection on >90% of the human genes revealed by the intrinsic replacement mutation rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

False-positive selection identified by ML-based methods: examples from the Sig1 gene of the diatom Thalassiosira weissflogii and the tax gene of a human T-cell lymphotropic virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Molecular evolution of microcephalin, a gene determining human brain size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Molecular shaping of the beak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Evolution of the mammalian MHC: natural selection, recombination, and convergent evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Investigating single nucleotide polymorphism (SNP) density in the human genome and its implications for molecular evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Diffusion models in population genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

Neutral mutation hypothesis test

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

FOUNDER EFFECTS AND THE RATE OF MITOCHONDRIAL DNA EVOLUTION IN HAWAIIAN DROSOPHILA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

The genetical theory of natural selection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

The "Sewell Wright Effect".

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

Likelihood-ratio tests for positive selection of human and mouse duplicate genes reveal nonconservative and anomalous properties of widely used methods

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

Homologous recombination and the pattern of nucleotide substitution in Ehrlichia ruminantium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

Shedding genomic ballast: extensive parallel loss of ancestral gene families in animals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

Variation in the pattern of synonymous and nonsynonymous difference between two fungal genomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

The Future of Data Analysis in Evolutionary Genomics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

A method for detecting positive selection at single amino acid sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

Distribution of the strength of selection against amino acid replacements in human proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.HDY.6801031

7 January 2021

Identifiers

DOI

10.1038/SJ.HDY.6801031

1 reference

PubMed ID

17622265

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

17622265