(Q34652138)

3 August 2017

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title

Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis (English)

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3 August 2017

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Yongfeng Shang

1

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3 August 2017

language of work or name

English

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publication date

1 May 2006

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3 August 2017

published in

Nature Reviews Cancer

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3 August 2017

volume

6

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3 August 2017

issue

5

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3 August 2017

page(s)

360-368

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https://scigraph.springernature.com/pub.10.1038/nrc1879

3 August 2017

exact match

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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

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Molecular determinants for the tissue specificity of SERMs

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Coregulator function: a key to understanding tissue specificity of selective receptor modulators

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Molecular mechanisms, physiological consequences and pharmacological implications of estrogen receptor action

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Nuclear receptor modifications and endocrine cell proliferation

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Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity

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Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor

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Adenosine 3',5'-monophosphate in rat uterus: acute elevation by estrogen

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Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes

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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta

21 January 2018

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Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus

21 January 2018

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Well-differentiated endometrial adenocarcinomas and poorly differentiated mixed mullerian tumors have altered ER and PR isoform expression

21 January 2018

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Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium.

21 January 2018

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The estrogen receptor (ER)alpha variant Delta5 exhibits dominant positive activity on ER-regulated promoters in endometrial carcinoma cells

21 January 2018

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Estrogen receptor mutations in human disease

21 January 2018

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Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human

21 January 2018

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Wild-type estrogen receptor (ERbeta1) and the splice variant (ERbetacx/beta2) are both expressed within the human endometrium throughout the normal menstrual cycle

21 January 2018

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Evaluation of mRNA expression of estrogen receptor beta and its isoforms in human normal and neoplastic endometrium

21 January 2018

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

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Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains

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Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

21 January 2018

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Mining the Complexities of the Estrogen Signaling Pathways for Novel Therapeutics

21 January 2018

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The Molecular Pharmacology of SERMs

21 January 2018

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Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo.

21 January 2018

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Lack of evidence for tamoxifen- and toremifene-DNA adducts in lymphocytes of treated patients.

21 January 2018

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Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen.

21 January 2018

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Understanding the genotoxicity of tamoxifen?

21 January 2018

1 reference

Tamoxifen up-regulates oestrogen receptor-alpha, c-fos and glyceraldehyde 3-phosphate-dehydrogenase mRNAs in ovine endometrium

21 January 2018

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In vivo regulation of syndecan-3 expression in the rat uterus by 17 beta-estradiol

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Regulation of estrogen target genes and growth by selective estrogen-receptor modulators in endometrial cancer cells

21 January 2018

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Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells

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Tamoxifen induction of angiogenic factor expression in endometrium

21 January 2018

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Estrogen receptor-mediated effects of tamoxifen on human endometrial cancer cells

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17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context

21 January 2018

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Target specificity of selective estrogen receptor modulators within human endometrial cancer cells

21 January 2018

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Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites

21 January 2018

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Differential SERM effects on corepressor binding dictate ERalpha activity in vivo

21 January 2018

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Combinatorial roles of the nuclear receptor corepressor in transcription and development

21 January 2018

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Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator

21 January 2018

1 reference

The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT

21 January 2018

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Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis

21 January 2018

1 reference

Identification of transcriptional biomarkers induced by SERMS in human endometrial cells using multivariate analysis of DNA microarrays

21 January 2018

1 reference

Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: signals that distinguish the human carcinogen tamoxifen

21 January 2018

1 reference

Endometrial effects of selective estrogen receptor modulators (SERMs) on estradiol-responsive gene expression are gene and cell-specific

21 January 2018

1 reference

Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements

21 January 2018

1 reference

Estrogen receptor (ER)-alpha, but not ER-beta, mediates regulation of the insulin-like growth factor I gene by antiestrogens

21 January 2018

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Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast

21 January 2018

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21 January 2018

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Expression of Pax2 and patterning of the chick inner ear.

21 January 2018

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The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney

21 January 2018

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PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]

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A PANorama of PAX genes in cancer and development

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Expression of the PAX2 oncogene in human breast cancer and its role in progesterone-dependent mammary growth

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Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor

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21 January 2018

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Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2

21 January 2018

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The Secreted Frizzled Related Protein 2 (SFRP2) Gene Is a Target of the Pax2 Transcription Factor

21 January 2018

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The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women

21 January 2018

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Promoter Hypermethylation as an Epigenetic Component in Type I and Type II Endometrial Cancers

21 January 2018

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Expression of Nuclear Transcription Factor PAX2 in Renal Biopsies of Juvenile Nephronophthisis

21 January 2018

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Molecular Analysis of Familial Endometrial Carcinoma: A Manifestation of Hereditary Nonpolyposis Colorectal Cancer or a Separate Syndrome?

21 January 2018

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21 January 2018

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Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology

31 March 2020

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K-ras mutations in endometrial carcinomas with microsatellite instability

31 March 2020

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The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways

31 March 2020

1 reference

Mutations and amplification of oncogenes in endometrial cancer

31 March 2020

1 reference

The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens

31 March 2020

1 reference

The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators

31 March 2020

1 reference

Exon deletions and variants of human estrogen receptor mRNA in endometrial hyperplasia and adenocarcinoma

31 March 2020

1 reference

Prevention of bone loss by EM-800 and raloxifene in the ovariectomized rat

31 March 2020

1 reference

Lack of evidence from HPLC 32P-post-labelling for tamoxifenDNA adducts in the human endometrium

31 March 2020

1 reference

Agonistic effect of tamoxifen is dependent on cell type, ERE-promoter context, and estrogen receptor subtype: functional difference between estrogen receptors alpha and beta

31 March 2020

1 reference

Activation of transcription by estrogen receptor alpha and beta is cell type- and promoter-dependent

31 March 2020

1 reference

Activation of a Uterine Insulin-Like Growth Factor I Signaling Pathway by Clinical and Environmental Estrogens: Requirement of Estrogen Receptor-α

31 March 2020

1 reference

Antiestrogens: mechanisms and actions in target cells

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1879

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Dimensions Publication ID

3 August 2017

1009898631

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Fatcat ID

release_2pcqrsczibhjhprr2eylz4mc6u

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2pcqrsczibhjhprr2eylz4mc6u

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference