(Q34660220)

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The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Andisheh Abedini

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Bruce C Verchere

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Daniel P Raleigh

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

author name string

Fanling Meng

1

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10 February 2020

Annette Plesner

3

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10 February 2020

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1 September 2010

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10 February 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

49

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

37

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

8127-8133

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

1 reference

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Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

1 reference

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A synergistic small-molecule combination directly eradicates diverse prion strain structures

1 reference

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A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides

1 reference

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Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol.

1 reference

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Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

1 reference

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7 July 2018

Peptide and protein mimetics inhibiting amyloid beta-peptide aggregation.

1 reference

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Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

1 reference

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7 July 2018

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

1 reference

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7 July 2018

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

1 reference

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7 July 2018

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

1 reference

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7 July 2018

Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

1 reference

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7 July 2018

Small-molecule aggregates inhibit amyloid polymerization

1 reference

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7 July 2018

Alzhemed: a potential treatment for Alzheimer's disease

1 reference

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7 July 2018

Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitus

1 reference

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7 July 2018

The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

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7 July 2018

Mechanism of prion propagation: amyloid growth occurs by monomer addition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Comparison of alamar blue and MTT assays for high through-put screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

7 July 2018

Islet amyloid polypeptide and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

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Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

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Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

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Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

1 reference

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Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1 reference

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A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas

1 reference

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Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

1 reference

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1 reference

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1 reference

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The insulin secretory granule

1 reference

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Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199968

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Small-molecule inhibitors of islet amyloid polypeptide fibril formation

1 reference

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1 reference

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1 reference

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Formation of amyloid in human pancreatic islets transplanted to the liver and spleen of nude mice

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The mechanism of insulin action on islet amyloid polypeptide fiber formation

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26 October 2018

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

1 reference

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Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20707388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/20707388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of Pseudoproline Derivatives Allows the Facile Synthesis of Human IAPP, a Highly Amyloidogenic and Aggregation-Prone Polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20707388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Single-Point Mutation Converts the Highly Amyloidogenic Human Islet Amyloid Polypeptide into a Potent Fibrillization Inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20707388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread amyloid deposition in transplanted human pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/20707388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI100939A

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20707388%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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