(Q34665690)

English

Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. (English)

1 reference

Europe PubMed Central

3 August 2017

Alzheimer's disease

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1 reference

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inferred from title

author name string

Youdim MB

1

1 reference

Europe PubMed Central

3 August 2017

Weinstock M

2

1 reference

Europe PubMed Central

3 August 2017

language of work or name

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based on heuristic

inferred from title

publication date

1 December 2001

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Europe PubMed Central

3 August 2017

Cellular and Molecular Neurobiology

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Europe PubMed Central

3 August 2017

21

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Europe PubMed Central

3 August 2017

6

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Europe PubMed Central

3 August 2017

555-573

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Europe PubMed Central

3 August 2017

https://scigraph.springernature.com/pub.10.1023/a:1015131516649

0 references

Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective acetylenic 'suicide' and reversible inhibitors of monoamine oxidase types A and B

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyramine antagonistic properties of AGN 1135, an irreversible inhibitor of monoamine oxidase type B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 over-expression and activation of protein kinase C suppress the trail-induced apoptosis in Jurkat T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of MPTP-induced neurotoxicity by AGN-1133 and AGN-1135, selective inhibitors of monoamine oxidase-B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline Mesylate, a New Mao-B Inhibitor for the Treatment of Parkinson's Disease: A Double-Blind Study as Adjunctive Therapy to Levodopa

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors: a therapeutic strategy for Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of rasagiline (N-propargyl-1R-aminoindan).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced apoptosis after nerve growth factor and serum withdrawal: conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of low-dose treatment with selegiline on dopamine transporter (DAT) expression and amphetamine-induced dopamine release in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(R)(+)-N-propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors increase secretion of APPs in rat brain cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-coupled amyloid precursor protein processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of amyloid precursor protein cleavage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of cholinesterase inhibitors on the secretion of APPS from rat brain cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sparing by rasagiline (TVP-1012) of cholinergic functions and behavior in the postnatal anoxia rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies with rasagiline, a MAO-B inhibitor, in experimental focal ischemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuronal survival effects of rasagiline and deprenyl on fetal human and rat ventral mesencephalic neurones in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible neurotransmitter basis of behavioral changes in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presidental address. Neuropathological aspects of brain edema

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prevalence of depression in Alzheimer's disease and vascular dementia in a population sample.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptotic function of L-(-)deprenyl (Selegiline) and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of traumatic brain injury on the cholinergic system in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and neuroprotective properties of rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of blood pressure and nictitating membrane response to sympathetic amines by selective monoamine oxidase inhibitors, types A and B, in the cat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12043833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1015131516649

1 reference

Europe PubMed Central

3 August 2017

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1 reference

Europe PubMed Central

3 August 2017

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