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Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism.
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scholarly article
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Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
review article
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Europe PubMed Central
title
Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
author
Marco Racchi
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
Stefano Govoni
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2
1 reference
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Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
author name string
M Racchi
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1
1 reference
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Europe PubMed Central
PubMed ID
10498955
retrieved
29 July 2017
S Govoni
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2
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
retrieved
29 July 2017
publication date
1 October 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
published in
Trends in Pharmacological Sciences
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
volume
20
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
issue
10
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
page(s)
418-423
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
cites work
Translating cell biology into therapeutic advances in Alzheimer's disease
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Crossref
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7 January 2021
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Mechanisms of neuronal degeneration in Alzheimer's disease
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Crossref
reference URL
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7 January 2021
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Amyloid, the presenilins and Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
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7 January 2021
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Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
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7 January 2021
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Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regional alterations in M1 muscarinic receptor-G protein coupling in Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diminished [3H]inositol(1,4,5)P3 but not [3H]inositol(1,3,4,5)P4 binding in Alzheimer's disease brain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
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inferred from DOI database lookup
Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and possible correlation to pathological severity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of the phosphoinositide signalling system in the pathogenesis of sporadic Alzheimer's disease: a hypothesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C activation increases release of secreted amyloid precursor protein without decreasing Abeta production in human primary neuron cultures.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase A phosphorylation of the proteasome: a contribution to the alpha-secretase pathway in human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabotropic glutamate receptors increase amyloid precursor protein processing in astrocytes: inhibition by cyclic AMP.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Changes in beta amyloid precursor protein secretion associated with the proliferative status of CNS derived progenitor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phorbol esters but not the cholinergic agonists oxotremorine-M and carbachol increase release of the amyloid precursor protein in cultured rat cortical neurons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulated secretion of beta-amyloid precursor protein in rat brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholinesterase inhibitors increase secretion of APPs in rat brain cortex.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo regulation of amyloid precursor protein secretion in rat neocortex by cholinergic activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bradykinin-induced amyloid precursor protein secretion: a protein kinase C-independent mechanism that is not altered in fibroblasts from patients with sporadic Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2899%2901380-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-6147(99)01380-2
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
Fatcat ID
release_hi3ypc6zxvfp3k3tp2j72xot7y
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/hi3ypc6zxvfp3k3tp2j72xot7y
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
PubMed ID
10498955
1 reference
stated in
Europe PubMed Central
PubMed ID
10498955
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498955%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 October 2019
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