(Q34667222)

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Why (--)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

Why (--)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects (English)

1 reference

Europe PubMed Central

3 August 2017

author name string

Kenichi Kitani

1

1 reference

Europe PubMed Central

3 August 2017

Chiyoko Minami

2

1 reference

Europe PubMed Central

3 August 2017

Ken-ichi Isobe

3

1 reference

Europe PubMed Central

3 August 2017

Kayoko Maehara

4

1 reference

Europe PubMed Central

3 August 2017

Setsuko Kanai

5

1 reference

Europe PubMed Central

3 August 2017

Gwen O Ivy

6

1 reference

Europe PubMed Central

3 August 2017

Maria-Christina Carrillo

7

1 reference

Europe PubMed Central

3 August 2017

publication date

1 April 2002

1 reference

Europe PubMed Central

3 August 2017

Mechanisms of Ageing and Development

1 reference

Europe PubMed Central

3 August 2017

123

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Europe PubMed Central

3 August 2017

8

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Europe PubMed Central

3 August 2017

1087-1100

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Europe PubMed Central

3 August 2017

L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term treatment of male F344 rats with deprenyl: assessment of effects on longevity, behavior, and brain function.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

(-) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

(-)Deprenyl increases activities of superoxide dismutase and catalase in striatum but not in hippocampus: the sex and age-related differences in the optimal dose in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The ability of (-)deprenyl to increase superoxide dismutase activities in the rat is tissue and brain region selective

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The optimal dosage of (-)deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of a long term (6 months) treatment with (-)deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of nitrite formation from hydroxylammoniumchloride: a simple assay for superoxide dismutase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term administration of (-)-deprenyl increases mortality in male Wistar rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Aging: a theory based on free radical and radiation chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Report of the IDECG Working Group on the biology of aging. The International Dietary Energy Consultative Group

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic treatment of aged mice with L-deprenyl produces marked striatal MAO-B inhibition but no beneficial effects on survival, motor performance, or nigral lipofuscin accumulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Upregulation of antioxidant enzyme activities by deprenyl. Implications for life span extension

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Assessing the effects of deprenyl on longevity and antioxidant defenses in different animal models.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

L-deprenyl reduces brain damage in rats exposed to transient hypoxia-ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Trophic effects of selegiline on cultured dopaminergic neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

L-deprenyl potentiates NGF-induced changes in superoxide dismutase mRNA in PC12 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dietary restriction

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Maintenance on L-deprenyl prolongs life in aged male rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Physical-chemical and biochemical differences in liver plasma membranes in aging F-344 rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

(-)Deprenyl reduces delayed neuronal death of hippocampal pyramidal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment with L-deprenyl prolongs life in elderly dogs

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage.

1 reference

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7 January 2021

based on heuristic

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Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Establishment of an Aging Farm of F344/N Rats and C57BL/6 Mice at the National Institute for Longevity Sciences (NILS)

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

(-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of deprenyl (selegiline) on the natural history of Parkinson's disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of deprenyl on the progression of disability in early Parkinson's disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of sympathetic noradrenergic nerve fibers in the spleen by low doses of L-deprenyl treatment in young sympathectomized and old Fischer 344 rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

L-deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of noradrenergic nerve fibers in the spleens of old F344 rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

L-deprenyl inhibits tumor growth, reduces serum prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced mammary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of splenic noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-deprenyl and L-desmethyldeprenyl

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-tumor effect of L-deprenyl is associated with enhanced central and peripheral neurotransmission and immune reactivity in rats with carcinogen-induced mammary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of neuroendocrine--immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic and extrahepatic metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Aging and oxidative stress: modulation by dietary restriction

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Selegiline as immunostimulant--a novel mechanism of action?

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900392-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0047-6374(01)00392-X

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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