(Q34667753)

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The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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1 reference

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inferred from title

B-cell chronic lymphocytic leukemia

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based on heuristic

inferred from title

Tait D Shanafelt

5

object named as

Tait D Shanafelt

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Justin C. Boysen

3

object named as

Justin Boysen

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

7

object named as

Neil E Kay

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1

object named as

Asish K Ghosh

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Charla R. Secreto

2

object named as

Charla Secreto

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Traci Sassoon

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Debabrata Mukhopadhyay

6

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Europe PubMed Central

PubMed publication ID

3 August 2017

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publication date

6 December 2010

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

117

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Europe PubMed Central

PubMed publication ID

3 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1928-1937

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

The vascular endothelial growth factor receptor tyrosine kinase inhibitors vatalanib and pazopanib potently induce apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo

1 reference

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Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression

1 reference

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Src kinases as therapeutic targets for cancer

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Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition

1 reference

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Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis

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Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.

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Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells

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Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG.

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Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

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Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

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Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.

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The reactive oxygen-driven tumor: relevance to melanoma

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AXL is a potential target for therapeutic intervention in breast cancer progression.

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The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

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A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

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Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch".

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

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Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases

1 reference

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Expression of axl in lung adenocarcinoma and correlation with tumor progression

1 reference

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Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis

1 reference

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Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.

1 reference

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

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Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family

1 reference

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Expression of the proto-oncogene Axl in renal cell carcinoma

1 reference

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Clinical significance of AXL kinase family in gastric cancer

1 reference

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Biology of chronic lymphocytic leukemia

1 reference

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Oncogenic kinase signalling

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Cell signaling by receptor tyrosine kinases

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The Hallmarks of Cancer

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Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance

1 reference

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Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site

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Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress

1 reference

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1 reference

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Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

1 reference

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Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme

1 reference

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The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease.

1 reference

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Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation

1 reference

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VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance

1 reference

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Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells

1 reference

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VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia

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Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance

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Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

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26 October 2018

Expression profile of tyrosine kinases in breast cancer.

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Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.

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26 October 2018

Identifiers

10.1182/BLOOD-2010-09-305649

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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