(Q34671726)

3 August 2017

title

Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps (English)

1 reference

3 August 2017

1

0 references

Emmanuel Barillot

object named as

Emmanuel Barillot

series ordinal

3

0 references

Wolf-Dietrich Heyer

series ordinal

4

object named as

Wolf-Dietrich Heyer

1 reference

3 August 2017

Inna Kuperstein

2

1 reference

3 August 2017

publication date

4 April 2013

1 reference

PLOS Computational Biology

3 August 2017

published in

1 reference

3 August 2017

volume

9

1 reference

3 August 2017

issue

4

1 reference

3 August 2017

page(s)

e1003016

1 reference

Creative Commons Attribution 4.0 International

3 August 2017

copyright license

start time

4 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings

7 July 2018

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7 July 2018

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Putting genetic interactions in context through a global modular decomposition

7 July 2018

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Protein complexes are central in the yeast genetic landscape

7 July 2018

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Rad52 inactivation is synthetically lethal with BRCA2 deficiency

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

7 July 2018

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Clinical review: oxygen as a signaling molecule

7 July 2018

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Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements

7 July 2018

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Regulation of homologous recombination in eukaryotes

7 July 2018

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Chaperone networks: tipping the balance in protein folding diseases

7 July 2018

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Mechanisms, regulation and consequences of protein SUMOylation

7 July 2018

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Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

7 July 2018

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Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity

7 July 2018

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The genetic landscape of a cell

7 July 2018

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Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

7 July 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Functional maps of protein complexes from quantitative genetic interaction data

7 July 2018

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Quality control of DNA break metabolism: in the 'end', it's a good thing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

The consequences of Rad51 overexpression for normal and tumor cells

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Profiling essential genes in human mammary cells by multiplex RNAi screening

7 July 2018

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Homologous recombination in DNA repair and DNA damage tolerance

7 July 2018

1 reference

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Concepts in sumoylation: a decade on

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Utilizing RNA interference to enhance cancer drug discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Exploring genetic interactions and networks with yeast

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Some disassembly required: role of DNA translocases in the disruption of recombination intermediates and dead-end complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Rad54: the Swiss Army knife of homologous recombination?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Mapping pathways and phenotypes by systematic gene overexpression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Systematic interpretation of genetic interactions using protein networks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Signaling through monoubiquitination.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

7 July 2018

Biological robustness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

DNA helicase Srs2 disrupts the Rad51 presynaptic filament

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Systematic genetic analysis with ordered arrays of yeast deletion mutants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Chlorambucil induction of HsRad51 in B-cell chronic lymphocytic leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Integrating genetic approaches into the discovery of anticancer drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Establishing genetic interactions by a synthetic dosage lethality phenotype.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Suppression of a new allele of the yeast RAD52 gene by overexpression of RAD51, mutations in srs2 and ccr4, or mating-type heterozygosity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Biological networks: the tinkerer as an engineer.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003016

Genetics of natural populations; recombination and variability in populations of Drosophila pseudoobscura

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617211

Asymptotology of chemical reaction networks

26 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003016

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23592964

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PCBI.1003016

1 reference

journals/ploscb/ZinovyevKBH13

3 August 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

3 August 2017

1 reference