(Q34673148)

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Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Alzheimer's disease

0 references

author name string

Alan P Kozikowski

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Yihua Chen

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Tapadar Subhasish

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Nancy E Lewin

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Peter M Blumberg

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Zhenyu Zhong

6

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Melissa A D'Annibale

7

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Weng-Long Wang

8

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Yong Shen

9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Brett Langley

10

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

publication date

1 July 2009

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

1095-1105

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Histone deacetylase 6 interacts with the microtubule-associated protein tau

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Dietary histone deacetylase inhibitors: from cells to mice to man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

The aging brain, a key target for the future: the protein kinase C involvement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Recovery of learning and memory is associated with chromatin remodelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Histone deacetylase inhibitors: discovery and development as anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Histone deacetylases and cancer: causes and therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Genomewide studies of histone deacetylase function in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Regulation of protein kinase C betaII by its C2 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Regulation of protein kinase C: a tale of lipids and proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Defective protein kinase C alpha leads to impaired secretion of soluble beta-amyloid precursor protein from Alzheimer's disease fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Oxidative stress induces apoptosis in embryonic cortical neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Protein kinase C: structure, function, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Differential involvement of protein kinase C isozymes in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

7 July 2018

Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900045

21 January 2018

Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900045

21 January 2018

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900045

21 January 2018

Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

26 October 2018

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

26 October 2018

Histone Deacetylase Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

26 October 2018

Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

26 October 2018

Attenuated protein kinase C activity and translocation in Alzheimer's disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057395

26 October 2018

Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of protein kinase C mRNA levels in Alzheimer's disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme sele

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of protein kinase C in Alzheimer brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19396896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/CMDC.200900045

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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