(Q34680639)

3 August 2017

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title

Molecular causes of colon cancer (English)

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3 August 2017

Irma M Oving

1

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3 August 2017

Hans C Clevers

series ordinal

2

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3 August 2017

publication date

1 June 2002

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European Journal of Clinical Investigation

3 August 2017

published in

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3 August 2017

volume

32

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3 August 2017

issue

6

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3 August 2017

page(s)

448-457

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

3 August 2017

cites work

1 reference

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21 January 2018

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

21 January 2018

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Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

21 January 2018

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DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

21 January 2018

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Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.

21 January 2018

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Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

21 January 2018

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 January 2018

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The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

21 January 2018

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Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

beta-catenin is a target for the ubiquitin-proteasome pathway

21 January 2018

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beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

21 January 2018

1 reference

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Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

1 reference

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

All Tcf HMG box transcription factors interact with Groucho-related co-repressors

21 January 2018

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Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling.

21 January 2018

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The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Identification of c-MYC as a target of the APC pathway

21 January 2018

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Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Identification and characterization of the familial adenomatous polyposis coli gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Lessons from hereditary colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Association of the APC gene product with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Association of the APC tumor suppressor protein with catenins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Asef, a link between the tumor suppressor APC and G-protein signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Linking colorectal cancer to Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The many faces of the tumor suppressor gene APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The APC tumour suppressor has a nuclear export function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Functional domains of axin. Importance of the C terminus as an oligomerization domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

The oncogenic activation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Identification of FAP locus genes from chromosome 5q21

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Mutations of the APC (adenomatous polyposis coli) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Cancer. A CINtillating new job for the APC tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Over-expression of the c-myc proto-oncogene in colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Translocations among antibody genes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Matrilysin gene expression in sporadic and familial colorectal adenomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Molecular predictors of survival after adjuvant chemotherapy for colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

Matrilysin in early stage intestinal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.2002.01004.X

10.1046/J.1365-2362.2002.01004.X

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference