(Q34685308)

3 August 2017

Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes (English)

1 reference

3 August 2017

1 reference

2

Domenico Accili

1 reference

3 August 2017

Hua V Lin

1

1 reference

PubMed ID

21239487

3 August 2017

language of work or name

English

0 references

publication date

14 January 2011

1 reference

Journal of Biological Chemistry

3 August 2017

1 reference

3 August 2017

286

1 reference

3 August 2017

11

1 reference

3 August 2017

9797-9804

1 reference

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Hypothalamic K(ATP) channels control hepatic glucose production

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Transgenic rescue of insulin receptor-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Mosaic analysis of insulin receptor function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

In vivo mutagenesis of the insulin receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Distinct and overlapping functions of insulin and IGF-I receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Glucose transporter proteins in brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Alternative splicing of human insulin receptor messenger RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

GLUT4 glucose transporter expression in rodent brain: effect of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.210807

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059034

Mouse models of insulin resistance

26 October 2018

1 reference

12 December 2020

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1 reference

12 December 2020

Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis

1 reference

12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

12 December 2020

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

1 reference

12 December 2020

Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1

1 reference

12 December 2020

Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.210807

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

PubMed ID

21239487