(Q34687112)

3 August 2017

title

Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety (English)

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3 August 2017

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5

Matthias Staufenbiel

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3 August 2017

Yoshio Okura

1

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3 August 2017

Akira Miyakoshi

2

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3 August 2017

Kuniko Kohyama

3

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3 August 2017

Il-Kwon Park

4

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3 August 2017

Yoh Matsumoto

6

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3 August 2017

language of work or name

English

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publication date

12 June 2006

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

103

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3 August 2017

issue

25

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3 August 2017

page(s)

9619-9624

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Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease

3 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Toll-like receptor ligands directly promote activated CD4+ T cell survival

7 July 2018

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Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

7 July 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

7 July 2018

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Nonviral approaches satisfying various requirements for effective in vivo gene therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Nonviral vectors in the new millennium: delivery barriers in gene transfer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Characterization of T cell receptor (TCR) of organ-specific autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

CpG motifs in bacterial DNA trigger direct B-cell activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Pharmacological enhancement of in vivo foreign gene expression in muscle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Direct gene transfer into mouse muscle in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Pubertal changes in biochemical markers of growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Characterization of relapsing autoimmune encephalomyelitis and its treatment with decoy chemokine receptor genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Intra- and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1480456

Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Neuron loss in APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0600966103

Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmune encephalomyelitis

21 January 2018

1 reference

12 December 2020

Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity

1 reference

12 December 2020

Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway

1 reference

12 December 2020

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0600966103

1 reference

3 August 2017

0 references

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3 August 2017

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