(Q34694796)

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Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

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Europe PubMed Central

PubMed publication ID

4 August 2017

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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Christof von Kalle

8

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Christof von Kalle

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Immacolata Brigida

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Immacolata Brigida

5

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Alessandro Ambrosi

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Alessandro Ambrosi

2

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Alessandro Aiuti

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Alessandro Aiuti

10

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Maria Grazia Roncarolo

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Maria Grazia Roncarolo

6

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Manfred Schmidt

9

object named as

Manfred Schmidt

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Clelia Di Serio

7

object named as

Clelia Di Serio

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

author name string

Luca Biasco

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Danilo Pellin

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

Cynthia Bartholomae

4

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Europe PubMed Central

PubMed publication ID

4 August 2017

publication date

17 January 2011

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Europe PubMed Central

PubMed publication ID

4 August 2017

EMBO Molecular Medicine

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Europe PubMed Central

PubMed publication ID

4 August 2017

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

89-101

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Medicine. A comeback for gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

HIV integration site distributions in resting and activated CD4+ T cells infected in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Transcription factor binding sites are genetic determinants of retroviral integration in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Mechanisms governing lentivirus integration site selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Massively parallel pyrosequencing in HIV research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

High-resolution mapping and characterization of open chromatin across the genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Retroviral integration and human gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

High-resolution profiling of histone methylations in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Hot spots of retroviral integration in human CD34+ hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Retroviral DNA integration: viral and cellular determinants of target-site selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Transcription start regions in the human genome are favored targets for MLV integration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060339

7 July 2018

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

Gene therapy fulfilling its promise

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

Lymphoid-affiliated genes are associated with active histone modifications in human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

Resistance of mature T cells to oncogene transformation

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201000108

21 January 2018

Identifiers

10.1002/EMMM.201000108

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

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